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LTS and FS inhibitory interneurons, short-term synaptic plasticity, and cortical circuit dynamics

Hayut, I and Fanselow, EE and Connors, BW and Golomb, D (2011) LTS and FS inhibitory interneurons, short-term synaptic plasticity, and cortical circuit dynamics. PLoS Computational Biology, 7 (10). ISSN 1553-734X

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Abstract

Somatostatin-expressing, low threshold-spiking (LTS) cells and fast-spiking (FS) cells are two common subtypes of inhibitory neocortical interneuron. Excitatory synapses from regular-spiking (RS) pyramidal neurons to LTS cells strongly facilitate when activated repetitively, whereas RS-to-FS synapses depress. This suggests that LTS neurons may be especially relevant at high rate regimes and protect cortical circuits against over-excitation and seizures. However, the inhibitory synapses from LTS cells usually depress, which may reduce their effectiveness at high rates. We ask: by which mechanisms and at what firing rates do LTS neurons control the activity of cortical circuits responding to thalamic input, and how is control by LTS neurons different from that of FS neurons? We study rate models of circuits that include RS cells and LTS and FS inhibitory cells with short-term synaptic plasticity. LTS neurons shift the RS firing-rate vs. current curve to the right at high rates and reduce its slope at low rates; the LTS effect is delayed and prolonged. FS neurons always shift the curve to the right and affect RS firing transiently. In an RS-LTS-FS network, FS neurons reach a quiescent state if they receive weak input, LTS neurons are quiescent if RS neurons receive weak input, and both FS and RS populations are active if they both receive large inputs. In general, FS neurons tend to follow the spiking of RS neurons much more closely than LTS neurons. A novel type of facilitation-induced slow oscillations is observed above the LTS firing threshold with a frequency determined by the time scale of recovery from facilitation. To conclude, contrary to earlier proposals, LTS neurons affect the transient and steady state responses of cortical circuits over a range of firing rates, not only during the high rate regime; LTS neurons protect against over-activation about as well as FS neurons. © 2011 Hayut et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hayut, I
Fanselow, EE
Connors, BW
Golomb, D
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorGraham, Lyle J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 October 2011
Date Type: Publication
Journal or Publication Title: PLoS Computational Biology
Volume: 7
Number: 10
DOI or Unique Handle: 10.1371/journal.pcbi.1002248
Schools and Programs: School of Medicine > Neurobiology
Refereed: Yes
ISSN: 1553-734X
MeSH Headings: Action Potentials--physiology; Animals; Cerebral Cortex--physiology; Computational Biology; Electric Stimulation; Epilepsy, Absence--physiopathology; Humans; Interneurons--physiology; Models, Neurological; Neuronal Plasticity--physiology; Neurotransmitter Agents; Rats; Thalamus--physiology
Other ID: NLM PMC3203067
PubMed Central ID: PMC3203067
PubMed ID: 22046121
Date Deposited: 07 Sep 2012 20:41
Last Modified: 11 Feb 2018 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/13991

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