Belanger, AE and Porter, JC and Hatfull, GF
(2000)
Genetic analysis of peptidoglycan biosynthesis in mycobacteria: Characterization of a ddlA mutant of Mycobacterium smegmatis.
Journal of Bacteriology, 182 (23).
6854 - 6856.
ISSN 0021-9193
Abstract
A temperature-sensitive mutant of Mycobacterium smegmatis was characterized that contains a mutation in ddlA, the gene encoding D-alanine:D-alanine ligase. Enzymatic assays using recombinant proteins and D-cycloserine susceptibility indicate that the A365V mutation in the SMEG35 DdlA protein causes a reduction in enzymatic activity in vitro and in vivo.
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Details
| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Belanger, AE | | | | | Porter, JC | | | | | Hatfull, GF | gfh@pitt.edu | GFH | |
|
| Date: |
1 December 2000 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Journal of Bacteriology |
| Volume: |
182 |
| Number: |
23 |
| Page Range: |
6854 - 6856 |
| DOI or Unique Handle: |
10.1128/jb.182.23.6854-6856.2000 |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Biological Sciences |
| Refereed: |
Yes |
| ISSN: |
0021-9193 |
| MeSH Headings: |
Base Sequence; DNA, Bacterial; Gene Expression; Molecular Sequence Data; Mutagenesis; Mycobacterium smegmatis--enzymology; Mycobacterium smegmatis--genetics; Peptide Synthases--genetics; Peptide Synthases--metabolism; Peptidoglycan--biosynthesis; Temperature |
| Other ID: |
NLM PMC111435 |
| PubMed Central ID: |
PMC111435 |
| PubMed ID: |
11073937 |
| Date Deposited: |
12 Nov 2012 15:52 |
| Last Modified: |
27 Sep 2022 15:03 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/16125 |
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