Luffy, Sarah
(2013)
Magnesium Alloys for use as an Intraluminal Tracheal Stent.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Tracheal stenting is used for successful management of adult airway obstructions, including tracheal stenosis, a narrowing of the tracheal lumen due to trauma or prolonged intubation. The permanent nature of non-degradable tracheal stents makes them a treatment option of last resort for pediatric patients. Complications associated with stent removal and restenosis could be avoided with degradable tracheal stent placement. Magnesium alloys are demonstrating promise as degradable materials in orthopedic and cardiovascular applications, however the performance of magnesium alloys in the trachea remains unknown. This research explores three commercially available magnesium alloys for evaluation as degradable tracheal stents. The degradation behavior of these alloys was first evaluated in vivo as an intraluminal stent in a rat tracheal bypass model. Even after 6 months the stents persisted and degradation was assessed using microCT imaging. Significant differences in percent of total volume lost were found between alloys over time. Magnesium alloys were also evaluated in a bioreactor to simulate the airway environment and corrosion in vitro. Using ICP, the presence of magnesium from each alloy was measured in a simulated airway media and in a control media over 7 days. Significant differences in corrosion were observed between the simulated and control conditions for in vitro assessment of each alloy. Additionally, in vitro corrosion of magnesium alloys did not appear significantly different from the percent of total volume lost in vivo at the 1-week time point. This study demonstrates an approach to evaluating magnesium alloys as intraluminal tracheal stents. Further development of the alloys and stent design are required for a clinically translatable model.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
24 September 2013 |
| Date Type: |
Publication |
| Defense Date: |
12 March 2013 |
| Approval Date: |
24 September 2013 |
| Submission Date: |
17 April 2013 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
66 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Bioengineering |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
trachea, pediatric, magnesium, alloy, stent, stenosis |
| Date Deposited: |
24 Sep 2013 19:06 |
| Last Modified: |
19 Dec 2016 14:40 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/18436 |
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