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DEVELOPMENT OF ION MASS SPECTROMETRY-BASED INSTRUMENTATION AND APPLICATIONS

JIANG, WENTAO (2014) DEVELOPMENT OF ION MASS SPECTROMETRY-BASED INSTRUMENTATION AND APPLICATIONS. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Ion mobility spectrometry (IMS) is a technique that can rapidly separate ions based on their mobility in an inert buffer gas and provide insights to molecular structure. When coupled with mass spectrometry (MS), IM-MS offers a powerful hybrid analytical technique that has many biological, pharmaceutical, structural, environmental and other applications. During past decades, various types of IM-MS instruments have been built and applied, of which the most popular type is IMS-time of flight (TOF) MS. However, there are biological problems which require resolution higher than TOFMS can provide. The goal of my first project was to build a drift time IMS (DTIMS) and couple it with a commercial linear ion trap (LTQ) mass analyzer which can provide not only quick separation but also mass analysis capability. It can be used for analysis of complex biochemical samples and degradation mixtures for example. Furthermore, the IMS will be subsequently transferred to a LTQ Orbitrap-Velos MS to obtain mass data with high resolution and accuracy.
The second project focuses on the analysis of carbon nanotube (CNT) and graphene oxide (GO) degradation products using MS. In recent years different methods for carbon nanomaterial deg-radation have been developed and it is of interest to gain better understanding of the degradation process. MS is a suitable analysis method for the detection of intermediate mixtures with mole-cules of different molecular weight size. The objective of this project was to use MS and tandem MS data combined with other analytical techniques (e.g. nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR)) in order to identify and determine the structures of intermediate degradation products of CNT and GO, and understand degradation mechanisms.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
JIANG, WENTAOwej10@pitt.eduWEJ10
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairRobinson, RenĂ£ A. S.rena@pitt.eduRENA
Committee MemberGrabowski, Joseph J.joeg@pitt.eduJOEG
Committee MemberStar, Alexanderastar@pitt.eduASTAR
Date: 22 May 2014
Date Type: Publication
Defense Date: 17 April 2014
Approval Date: 22 May 2014
Submission Date: 15 April 2014
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 74
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: ion mobility, mass spectrometry, IM-MS, DTIMS, carbon nanotubes, graphene, graphene quantum dots, photo-Fenton reaction, degradation products
Date Deposited: 22 May 2014 19:17
Last Modified: 15 Nov 2016 14:19
URI: http://d-scholarship.pitt.edu/id/eprint/21376

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