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Wireless monitoring of liver hemodynamics in vivo

Akl, TJ and Wilson, MA and Ericson, MN and Farquhar, E and Coté, GL (2014) Wireless monitoring of liver hemodynamics in vivo. PLoS ONE, 9 (7).

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Abstract

Liver transplants have their highest technical failure rate in the first two weeks following surgery. Currently, there are limited devices for continuous, real-time monitoring of the graft. In this work, a three wavelengths system is presented that combines near-infrared spectroscopy and photoplethysmography with a processing method that can uniquely measure and separate the venous and arterial oxygen contributions. This strategy allows for the quantification of tissue oxygen consumption used to study hepatic metabolic activity and to relate it to tissue stress. The sensor is battery operated and communicates wirelessly with a data acquisition computer which provides the possibility of implantation provided sufficient miniaturization. In two in vivo porcine studies, the sensor tracked perfusion changes in hepatic tissue during vascular occlusions with a root mean square error (RMSE) of 0.135 mL/min/g of tissue. We show the possibility of using the pulsatile wave to measure the arterial oxygen saturation similar to pulse oximetry. The signal is also used to extract the venous oxygen saturation from the direct current (DC) levels. Arterial and venous oxygen saturation changes were measured with an RMSE of 2.19% and 1.39% respectively when no vascular occlusions were induced. This error increased to 2.82% and 3.83% when vascular occlusions were induced during hypoxia. These errors are similar to the resolution of a commercial oximetry catheter used as a reference. This work is the first realization of a wireless optical sensor for continuous monitoring of hepatic hemodynamics. © 2014 Akl et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Akl, TJ
Wilson, MAmaw125@pitt.eduMAW125
Ericson, MN
Farquhar, E
Coté, GL
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorBrody, James P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Centers: Other Centers, Institutes, Offices, or Units > Allegheny Observatory
Date: 14 July 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 7
DOI or Unique Handle: 10.1371/journal.pone.0102396
Schools and Programs: School of Medicine > Surgery
Refereed: Yes
Date Deposited: 23 Sep 2014 15:57
Last Modified: 24 Jan 2019 01:55
URI: http://d-scholarship.pitt.edu/id/eprint/23016

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