The Ancient Evolutionary History of Polyomaviruses

Buck, CB and Van Doorslaer, K and Peretti, A and Geoghegan, EM and Tisza, MJ and An, P and Katz, JP and Pipas, JM and McBride, AA and Camus, AC and McDermott, AJ and Dill, JA and Delwart, E and Ng, TFF and Farkas, K and Austin, C and Kraberger, S and Davison, W and Pastrana, DV and Varsani, A (2016) The Ancient Evolutionary History of Polyomaviruses. PLoS Pathogens, 12 (4). ISSN 1553-7366

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Abstract

Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billion years. Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages. The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Buck, CB Van Doorslaer, K Peretti, A Geoghegan, EM Tisza, MJ An, P pia1@pitt.edu PIA1 0000-0002-3080-2288 Katz, JP Pipas, JM pipas@pitt.edu PIPAS McBride, AA Camus, AC McDermott, AJ Dill, JA Delwart, E Ng, TFF Farkas, K Austin, C Kraberger, S Davison, W Pastrana, DV Varsani, A
Contributors:	Contribution Contributors Name Email Pitt Username ORCID Editor Galloway, Denise A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
Date:	1 April 2016
Date Type:	Publication
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title:	PLoS Pathogens
Volume:	12
Number:	4
DOI or Unique Handle:	10.1371/journal.ppat.1005574
Institution:	University of Pittsburgh
Schools and Programs:	Dietrich School of Arts and Sciences > Biological Sciences
Refereed:	Yes
ISSN:	1553-7366
Date Deposited:	05 Jul 2016 15:00
Last Modified:	25 Apr 2018 20:55
URI:	http://d-scholarship.pitt.edu/id/eprint/28531

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