Zheng, Hai and Zhao, Tiejun and Edelman, Kathryn and Qian, Yongxian and Ibrahim, Tamer S and Aizenstein, Howard and Boada, Fernando E
(2012)
Improved response to face recognition in UHF fMRI through parallel transmission RF pulse design.
In: 18th Annual Meeting of the Organization for Human Brain Mapping (OHBM) 2012, 10 June 2012 - 14 June 2012, Beijing, China.
Abstract
The amygdala plays an important role in normal memory and attention, and is also identified as a key structure to understand disorders with emotions such as depression, autism, and schizophrenia. Ultra high magnetic field (UHF) MRI has been used to depict anatomical details in the brain that are not attainable at lower field strengths. Unfortunately, UHF fMRI is problematic due to large magnetic susceptibiity-induced (SI) artifacts. This SI artifact manifests signal loss near important functional regions, such as the amygdala and limits the reliability of UHF fMRI studies in this region due to the coupling between the artifact level and the subject's underlying anatomy. People have proposed to restore the SI signal loss, but Radio frequency (RF) pulse durations are impractically long. In this study, we demonstrate a whole-brain, practical and robust RF pulse design to reliably recover the fMRI signal from the amygdala at ultra high field. We have successfully demonstrated that PTX 3DTRF design can be used for improving the fMRI signal response in amygdala. This is the first time that whole-brain, tailored RF methodology in conjunction with PTX RF has been demonstrated for this purpose. Overall, the proposed methodology was found to be robust across volunteers, especially when the 5-spoke trajectory was used.
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