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Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma

Bunyavanich, S and Melen, E and Wilk, JB and Granada, M and Soto-Quiros, ME and Avila, L and Lasky-Su, J and Hunninghake, GM and Wickman, M and Pershagen, G and O'Connor, GT and Weiss, ST and Celedn, JC (2011) Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clinical and Molecular Allergy, 9.

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Abstract

Background: Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied.Objective: To test for associations between variants in TSLP, TSLP-related genes, and AR in children with asthma.Methods: We genotyped 15 single nucleotide polymorphisms (SNPs) in TSLP, OX40L, IL7R, and RXRα in three independent cohorts: 592 asthmatic Costa Rican children and their parents, 422 nuclear families of North American children with asthma, and 239 Swedish children with asthma. We tested for associations between these SNPs and AR. As we previously reported sex-specific effects for TSLP, we performed overall and sex-stratified analyses. We additionally performed secondary analyses for gene-by-gene interactions.Results: Across the three cohorts, the T allele of TSLP SNP rs1837253 was undertransmitted in boys with AR and asthma as compared to boys with asthma alone. The SNP was associated with reduced odds for AR (odds ratios ranging from 0.56 to 0.63, with corresponding Fisher's combined P value of 1.2 × 10-4). Our findings were significant after accounting for multiple comparisons. SNPs in OX40L, IL7R, and RXRα were not consistently associated with AR in children with asthma. There were nominally significant interactions between gene pairs.Conclusions: TSLP SNP rs1837253 is associated with reduced odds for AR in boys with asthma. Our findings support a role for TSLP in the pathogenesis of AR in children with asthma. © 2011 Bunyavanich et al; licensee BioMed Central Ltd.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Bunyavanich, S
Melen, E
Wilk, JB
Granada, M
Soto-Quiros, ME
Avila, L
Lasky-Su, J
Hunninghake, GM
Wickman, M
Pershagen, G
O'Connor, GT
Weiss, ST
Celedn, JC
Date: 18 January 2011
Date Type: Publication
Journal or Publication Title: Clinical and Molecular Allergy
Volume: 9
DOI or Unique Handle: 10.1186/1476-7961-9-1
Schools and Programs: School of Public Health > Human Genetics
School of Medicine > Immunology
School of Medicine > Medicine
School of Medicine > Pediatrics
Refereed: Yes
Date Deposited: 16 Nov 2016 18:48
Last Modified: 19 Jun 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/30192

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