Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design

Menchetti, M and Bortolotti, B and Rucci, P and Scocco, P and Bombi, A and Berardi, D and Affatati, V and Alberini, G and Baranzini, F and Bellino, S and Bellomo, A and Blasi, T and Bogetto, F and Bortolaso, P and Callegari, C and Carpiniello, B and Colombini, N and Contu, C and Croci, G and De Salvia, M and Diurni, M and Elisei, S and Ferretti, M and Fiore, P and Fusar-Poli, P and Iuso, S and Lacalamita, A and La Ferla, T and Lia, L and Luciano, CC and Magnani, M and Manganaro, D and Martinelli, V and Martino, I and Montaguti, MB and Nespeca, C and Petito, A and Pinna, F and Piselli, M and Politi, P and Quartesan, R and Rella, A and Restaino, F and Rigatelli, M and Sciarini, P and Simoni, E and Succui, M and Tedeschini, E and Todarello, O and Vender, S and Zaccagni, L and Zizza, M and Lullini, G and Pedrini, E and D'Onghia, A and Mazza, M and Papagni, S (2010) Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design. BMC Psychiatry, 10.

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Abstract

Background: Depression is a frequently observed and disabling condition in primary care, mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression.Methods/Design: This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment.Discussion: This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures. © 2010 Menchetti et al; licensee BioMed Central Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Menchetti, M Bortolotti, B Rucci, P Scocco, P Bombi, A Berardi, D Affatati, V Alberini, G Baranzini, F Bellino, S Bellomo, A Blasi, T Bogetto, F Bortolaso, P Callegari, C Carpiniello, B Colombini, N Contu, C Croci, G De Salvia, M Diurni, M Elisei, S Ferretti, M Fiore, P Fusar-Poli, P Iuso, S Lacalamita, A La Ferla, T Lia, L Luciano, CC Magnani, M Manganaro, D Martinelli, V Martino, I Montaguti, MB Nespeca, C Petito, A Pinna, F Piselli, M Politi, P Quartesan, R Rella, A Restaino, F Rigatelli, M Sciarini, P Simoni, E Succui, M Tedeschini, E Todarello, O Vender, S Zaccagni, L Zizza, M Lullini, G Pedrini, E D'Onghia, A Mazza, M Papagni, S
Date:	25 November 2010
Date Type:	Publication
Journal or Publication Title:	BMC Psychiatry
Volume:	10
DOI or Unique Handle:	10.1186/1471-244x-10-97
Schools and Programs:	School of Medicine > Medicine School of Medicine > Psychiatry
Refereed:	Yes
Date Deposited:	16 Nov 2016 16:06
Last Modified:	20 Dec 2018 00:55
URI:	http://d-scholarship.pitt.edu/id/eprint/30210

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