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Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: A case report and further case studies

Yu, J and Bhargava, R and Dabbs, DJ (2010) Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: A case report and further case studies. Diagnostic Pathology, 5 (1).

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Abstract

Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presence of diffuse cytoplasmic p120 staining, confirming the lobular phenotype. The tumor cells showed ductal-like cytoplasmic MUC1 staining, but were negative for MUC2 and other mucin gene markers. In addition, studies of tissue microarrays of 80 breast carcinomas with mucinous differentiation revealed 4 pure mucinous carcinomas showing significantly reduced E-cadherin staining without redistribution of p120 into cytoplasm. The findings suggest that the presence of extracellular mucin does not exclude a diagnosis of lobular carcinoma, and the morphologic and molecular characteristics of lobular and ductal carcinomas are more complex than previously appreciated. © 2010 Yu et al; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Yu, Jjiy15@pitt.eduJIY15
Bhargava, Rrob24@pitt.eduROB24
Dabbs, DJdjd1@pitt.eduDJD1
Centers: Other Centers, Institutes, Offices, or Units > Magee-Women's Research Institute
Date: 15 June 2010
Date Type: Publication
Journal or Publication Title: Diagnostic Pathology
Volume: 5
Number: 1
DOI or Unique Handle: 10.1186/1746-1596-5-36
Schools and Programs: School of Medicine > Pathology
Refereed: Yes
Date Deposited: 10 Nov 2016 18:28
Last Modified: 02 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/30271

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