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DEVELOPMENT OF PROGRAMMABLE PEPTIDE CONSTRUCTS FOR CONTROLLING THE ASSEMBLY ARCHITECTURE AND PROPERTIES OF GOLD NANOPARTICLE SUPERSTRUCTURES AND SOFT MATERIALS

Merg, Andrea D. (2017) DEVELOPMENT OF PROGRAMMABLE PEPTIDE CONSTRUCTS FOR CONTROLLING THE ASSEMBLY ARCHITECTURE AND PROPERTIES OF GOLD NANOPARTICLE SUPERSTRUCTURES AND SOFT MATERIALS. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

This dissertation describes advances in the development of peptide-based methods for assembling nanomaterials. The aim of my work is four-fold: 1) develop methods to rationally tune the metrics of gold nanoparticle superstructures; 2) develop approaches to post-synthetically modify and stabilize gold nanoparticle superstructures; 3) develop an understanding of the underlying peptide assembly scaffold and how it dictates the final nanoparticle assembly architecture; and 4) develop new hybrid materials with peptide conjugate molecules having programmable R-groups.
Specifically, in Chapter 2 I describe methods to tune the assembly of double-helical gold nanoparticle superstructures by modulating the sterics and hydrophobicity of a family of new peptide conjugate molecules. I show that I can tune the assembly metrics of doubles helices including pitch, nanoparticle size, and interhelical distance. Chapter 3 describes the construction of single-helical gold nanoparticle superstructures that exhibit intense chiroptical activity. I examine their underlying peptide assembly structure and arrive at a molecular-level understanding of their assembly and how it relates to the chiral nanoparticle superstructure. In Chapter 4, I demonstrate a straightforward approach to rationally tune the metrics of hollow spherical gold nanoparticle superstructures including nanoparticle coverage density and sphere diameters. I further demonstrate that their assembly can be stabilized post-synthetically via ligand exchange. Finally, in Chapter 5 I design new peptide conjugate building blocks composed of peptides and oligonucleotides interlinked by a hydrophobic organic core. I outline design rules that govern their assembly and show that their assembly morphology can be rationally predicted and altered.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Merg, Andrea D.anm179@pitt.eduanm1790000-0002-2293-5267
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairRosi, Nathanielnrosi@pitt.edu0000-0001-8025-8906
Committee MemberHorne, W. Sethhorne@pitt.edu
Committee MemberWeber, Stephensweber@pitt.edu
Committee Membervan der Wel, Patrickpvdwel@pitt.edu
Date: 28 September 2017
Date Type: Publication
Defense Date: 26 April 2017
Approval Date: 28 September 2017
Submission Date: 5 July 2017
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 191
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Nanoparticle Assembly, Self-assembly, Peptide Assembly, Chiroptical Properties
Date Deposited: 28 Sep 2017 21:40
Last Modified: 29 Sep 2019 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/32700

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  • DEVELOPMENT OF PROGRAMMABLE PEPTIDE CONSTRUCTS FOR CONTROLLING THE ASSEMBLY ARCHITECTURE AND PROPERTIES OF GOLD NANOPARTICLE SUPERSTRUCTURES AND SOFT MATERIALS. (deposited 28 Sep 2017 21:40) [Currently Displayed]

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