Starzl, Thomas E and Scanlan, William A and Thornton, Fred H and Wendel, Robert M and Stearn, Burton and Lazarus, Robert E and McAllister, William and Shoemaker, William C
(1965)
Effect of insulin on glucose metabolism in the dog after portacaval transposition.
American Journal of Physiology-Legacy Content, 209 (1).
221 - 226.
ISSN 0002-9513
Abstract
<jats:p> The effect of insulin on hepatic glucose metabolism was studied by a multiple-catheter technique in unanesthetized dogs with Eck fistula and with portacaval transposition. With the latter preparation, blood entering and leaving the liver was sampled from peripherally inserted catheters. In the unanesthetized Eck-fistula animals, insulin infusion produced a decrease in the hepatic glucose output. In the dogs with portacaval transposition, a constant infusion of insulin was given alternately by systemic and by intraportal routes. There was no significant difference between the effects of insulin administered by the two routes. During insulin infusion, glucose concentration differences across the liver were reduced, hepatic plasma flow was transiently elevated, and hepatic glucose output was decreased. After discontinuance of insulin, there was a transient rise of hepatic glucose output to above control values. </jats:p>
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Starzl, Thomas E | tes11@pitt.edu | TES11 | | | Scanlan, William A | | | | | Thornton, Fred H | | | | | Wendel, Robert M | | | | | Stearn, Burton | | | | | Lazarus, Robert E | | | | | McAllister, William | | | | | Shoemaker, William C | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 July 1965 |
| Date Type: |
Publication |
| Journal or Publication Title: |
American Journal of Physiology-Legacy Content |
| Volume: |
209 |
| Number: |
1 |
| Publisher: |
American Physiological Society |
| Page Range: |
221 - 226 |
| DOI or Unique Handle: |
10.1152/ajplegacy.1965.209.1.221 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0002-9513 |
| Other ID: |
uls-drl:31735062122951, Starzl CV No. 44 |
| Date Deposited: |
08 Apr 2010 16:59 |
| Last Modified: |
04 Aug 2020 18:56 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/3430 |
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