Alhomrany, Yazeed/M
(2018)
Association Between BRINP3 Genetic Variation and Aggressive Periodontitis Among Arab Descents.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Background: Aggressive periodontitis disease is a severe type of periodontal disease, which is characterized by enormous destruction of periodontal attachment and alveolar bone. A few loci have shown to be associated with aggressive periodontitis, which suggest a multifactorial genetic component. BRINP3 locus shows correlation with aggressive periodontitis.
Aims: To replicate the initial findings of the relationship between aggressive periodontitis and BRINP3 genetic variation (rs1342913) in group of Arab subjects.
Methods: 263 subjects were diagnosed with aggressive periodontitis. They are originally from Syria and Morocco. They are divided into: diseased (with aggressive periodontitis n= 200. Among them 49 from Syria and 151 from Morocco). and healthy (without aggressive periodontitis n= 63). Saliva was collected, then genomic DNA was extracted. One genetic marker was genotyped (BRINP3 rs1342913). PCR was run with TaqMan chemistry. Chi-square with alpha of 0.05 was utilized to test over-representation of genotypes or alleles between two groups.
Result: The frequency AA genotype is higher than GG genotype. No significant difference between allele A and allele G.
Conclusion: The frequency BRINP3 is higher in aggressive periodontitis compared with healthy cases in Arab population. Based on this result, BRINP3 gene is associated with aggressive periodontists.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Alhomrany, Yazeed/M | | yma13@pitt.edu | |
|
| ETD Committee: |
| Title | Member | Email Address | Pitt Username | ORCID |
|---|
| Committee Member | Williams, Kelly/L | | kellywilliams@pitt.edu | | | Committee Member | Sfeir, Charles/S | | csfeir@pitt.edu | | | Committee Chair | Vieira, Alexandre/ R | | alexandre_vieira@pitt.edu | |
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| Date: |
30 July 2018 |
| Date Type: |
Publication |
| Defense Date: |
29 May 2018 |
| Approval Date: |
30 July 2018 |
| Submission Date: |
25 July 2018 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
25 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Dental Medicine > Dental Science |
| Degree: |
MDS - Master of Dental Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Aggressive periodontitis, BRINP3, Genotype, alleles, Dominant, Recessive. |
| Date Deposited: |
30 Jul 2018 15:02 |
| Last Modified: |
02 Aug 2018 19:08 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/35015 |
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