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IMMUNOPATHOLOGICAL STUDIES OF ORTHOTOPIC HUMAN LIVER ALLOGRAFTS

Andres, GA and Ansell, ID and Halgrimson, CG and Hsu, KC and Porter, KA and Starzl, TE and Accinni, L and Calne, RY and Herbertson, BM and Penn, I and Rendall, JM and Williams, R (1972) IMMUNOPATHOLOGICAL STUDIES OF ORTHOTOPIC HUMAN LIVER ALLOGRAFTS. The Lancet, 299 (7745). 275 - 280. ISSN 0140-6736

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Abstract

Twenty-six specimens obtained from twenty human orthotopic liver allografts 10-968 days after transplantation were studied by light microscopy, electron microscopy, and immunofluorescence. The main lesions consisted of mononuclear-cell infiltration around the portal tracts, centrilobular cholestasis, liver-cell atrophy and reticulin collapse, obliterative intimal thickening of hepatic arteries, and fibrosis. Moderate amounts of IgG and/or IgM and complement (β1C/β1A globulin or C'lq) were observed in four of the liver samples and smaller deposits were present in another five. A further three specimens contained IgG without complement. IgA was detected in only one of the samples. The immunoglobulins were found in the walls of the portal and central veins and of the sinusoids in all thirteen positive liver samples, in the walls of branches of the hepatic artery in three, and in the cytoplasm of some of the mononuclear cells infiltrating the portal tracts in nine of the specimens. Fibrinogen was seen in eight of the samples, usually in the spaces of Disse. Accumulations of immunoglobulins and complement were less frequent in liver than in kidney and heart allografts. These findings suggest that in the failure of human liver allografts cell-mediated immunity and non-immunological factors may be more important than humoral antibody. © 1972.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Andres, GA
Ansell, ID
Halgrimson, CG
Hsu, KC
Porter, KA
Starzl, TEtes11@pitt.eduTES11
Accinni, L
Calne, RY
Herbertson, BM
Penn, I
Rendall, JM
Williams, R
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 5 February 1972
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 299
Number: 7745
Page Range: 275 - 280
DOI or Unique Handle: 10.1016/s0140-6736(72)90288-7
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062108737, Starzl CV No. 268
PubMed ID: 4109928
Date Deposited: 08 Apr 2010 17:04
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/3654

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