Corman, JL and Putnam, CW and Iwatsuki, S and Redeker, AG and Porter, KA and Peters, RL and Schröter, G and Starzl, TE
(1979)
Liver Allograft: Its Use in Chronic Active Hepatitis with Macronodular Cirrhosis, Hepatitis B Surface Antigen.
Archives of Surgery, 114 (1).
75 - 78.
ISSN 0004-0010
Abstract
A patient suffering from chronic active hepatitis with macronodular cirrhosis, positive for hepatitis B surface antigen (HBsAg), was treated with an orthotopic liver allograft. The HBs antigenemia, as measured with several precipitation tests and by complement fixation, became negative after transplantation and remained so for about 2½ months. During the interval, very low titers of the antigen were detectable by radioimmunoassay. At about three months after transplantation, she had an attack of acute hepatitis, at which time HBsAg became detectable by all tests. She recovered, but progressive liver disease developed during the remaining 1½ years of her life. She died of disseminated nocardiosis and candidiasis with deteriorating hepatic function. The homograft at autopsy showed no evidence of rejection, but was the site of chronic active liver disease, although of a different pathologic pattern than that affecting her native liver. The differences in histology may reflect the influence of chronic immunosuppression on the features of chronic active hepatitis. © 1979, American Medical Association. All rights reserved.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Corman, JL | | | | | Putnam, CW | | | | | Iwatsuki, S | | | | | Redeker, AG | | | | | Porter, KA | | | | | Peters, RL | | | | | Schröter, G | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1979 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Archives of Surgery |
| Volume: |
114 |
| Number: |
1 |
| Page Range: |
75 - 78 |
| DOI or Unique Handle: |
10.1001/archsurg.1979.01370250077016 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0004-0010 |
| Other ID: |
uls-drl:31735062109438, Starzl CV No. 341 |
| Date Deposited: |
08 Apr 2010 17:05 |
| Last Modified: |
22 Jun 2021 10:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/3727 |
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