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Homotransplantation of the liver in a patientwith hepatoma and hereditary tyrosinemia

Fisch, RO and McCabe, ERB and Doeden, D and Koep, LJ and Kohlhoff, JG and Silverman, A and Starzl, TE (1978) Homotransplantation of the liver in a patientwith hepatoma and hereditary tyrosinemia. The Journal of Pediatrics, 93 (4). 592 - 596. ISSN 0022-3476

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Abstract

A girl with hereditary tyrosinemia, diagnosed at 6 months of age, was treated with a diet restricted inphenylalanine and tyrosine. At 91/2 years of age she developed an acutely enlarged liver and spleen, and the diagnosis of hepatocarcinoma was made. The patient received a liver transplant and tyrosine metabolites became normal while she was receiving a regular diet. Three months later, an infected thrombosis of the portal vein caused her death. Liver transplant appears to be an effective method of enzyme replacement in tyrosinemia and should be considered for prevention of hepatoma. © 1978 The C. V. Mosby Company.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Fisch, RO
McCabe, ERB
Doeden, D
Koep, LJ
Kohlhoff, JG
Silverman, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1978
Date Type: Publication
Journal or Publication Title: The Journal of Pediatrics
Volume: 93
Number: 4
Page Range: 592 - 596
DOI or Unique Handle: 10.1016/s0022-3476(78)80893-2
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-3476
Other ID: uls-drl:31735062109966, Starzl CV No. 395
Date Deposited: 08 Apr 2010 17:06
Last Modified: 02 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/3781

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