Clifton, Michelle
(2020)
Periaortic Adipose Tissue Relationship with Arterial Stiffness in Midlife Men.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Aims: Cardiovascular disease (CVD) remains as a major health concern and leading cause of death in the United states in men. Arterial stiffness is part of the aging process that alters function and may eventually lead to adverse cardiovascular event. Carotid-femoral pulse wave velocity (cfPWV) is a gold standard way of measuring stiffening of the artery and widely accepted predictor of CVD. Periaortic adipose tissue (aPVAT) is recent emerging risk marker for CVD. Because of its anatomy, aPVAT may have direct effect on vascular function. We hypothesize that aPVAT surrounding descending thoracic aorta is associated with cfPWV in biracial middle-aged men population. Then, we examined if the race moderates the relationship between aPVAT and cfPWV.
Methods: Participants were 40-49 years old and were free of CVD, type-1-diabetes, or other severe disease at the time of the recruit (n=324). cfPWV was quantified using automated waveform analyzer and aPVAT was quantified using EBT with standard attenuation values for adipose tissue (-190 to -30 HU). aPVAT volume was calculated by summing the areas and multiplying by the slice thickness.
Results: White men had higher aPVAT volume (p=0.011) but cfPWV was higher in African-American men (p=0.66). aPVAT was associated with cfPWV independent of traditional CVD risk factors (p=0.005). The association between aPVAT and cfPWV persisted after adjusting adiposity measurements, such as VAT (p=0.054)or WC (p=0.038), or BMI (p=0.052), CRP, and hypertensive, lipid, and diabetes medications. Race did not moderate the relationship between aPVAT and cfPWV (p=0.418).
Conclusion: Middle-aged men with high periaortic fat volume are more likely to have stiffer arteries independent of traditional CVD risk factors, adiposity measurements, an inflammation marker, and medications related to aPVAT and cfPWV. This work contributes to the field of public health by deepening understanding of vascular function through aPVAT in middle-aged men.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
| Title | Member | Email Address | Pitt Username | ORCID |
|---|
| Thesis Advisor | Barinas-Mitchell, Emma | | | | | Committee Member | Sekikawa, Akira | | | | | Committee Member | Althouse, Andrew | | | |
|
| Date: |
30 July 2020 |
| Date Type: |
Publication |
| Defense Date: |
13 April 2020 |
| Approval Date: |
30 July 2020 |
| Submission Date: |
30 March 2020 |
| Access Restriction: |
2 year -- Restrict access to University of Pittsburgh for a period of 2 years. |
| Number of Pages: |
59 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Epidemiology |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
periaortic fat arterial stiffness men |
| Date Deposited: |
30 Jul 2020 18:06 |
| Last Modified: |
01 May 2022 05:15 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/38440 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[feed]](/images/feed-icon-32x32.png){kind=icon}