Starzl, TE and Klintmalm, GBG and Weil, R and Porter, KA and Iwatsuki, S and Schroter, GP and Fernandez-Bueno, C and MacHugh, N
(1981)
Cyclosporin A and steroid therapy in sixty-six cadaver kidney recipients.
Surgery Gynecology and Obstetrics, 153 (4).
486 - 494.
ISSN 0039-6087
Abstract
From nine to 18 months ago, 66 patients were given 67 randomly matched cadaveric kidneys with cyclosporin A and steroid therapy. Nine of the recipients were undergoing retransplantation. The over-all kidney survival rate to date has been 77.6 per cent, and 78.8 per cent of the recipients are dialysis-free. The patient mortality in this learning phase was 13.3 per cent. Nephrotoxicity, hepatotoxicity and other side-effects of cyclosporin A could usually be dealt with by dosage adjustments, making feasible the chronic use of this agent. One B-cell immunoblastic sarcoma was encountered which was monoclonal. It was not responsible for death. Another patient had a perforation of the intestine from a lymphoproliferative reaction in which the B cells were polyclonal. After jejunal resection a year ago, there were no further complications. This lesion was not classified as a lymphoma. Both lymphoproliferative lesions were associated with a rise in antibody to viral capsid antigen of Epstein-Barr virus. Results of this study have verified the effectiveness and relative safety of cyclosporin A with steroids for immunosuppression in human recipients of cadaveric kidneys.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Starzl, TE | tes11@pitt.edu | TES11 | | | Klintmalm, GBG | | | | | Weil, R | | | | | Porter, KA | | | | | Iwatsuki, S | | | | | Schroter, GP | | | | | Fernandez-Bueno, C | | | | | MacHugh, N | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
20 November 1981 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Surgery Gynecology and Obstetrics |
| Volume: |
153 |
| Number: |
4 |
| Page Range: |
486 - 494 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0039-6087 |
| Other ID: |
uls-drl:31735062114354, Starzl CV No. 469 |
| Date Deposited: |
08 Apr 2010 17:07 |
| Last Modified: |
02 Feb 2019 13:56 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/3855 |
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