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The Clearance of Cyclosporine by Hemodialysis

VENKATARAMANAN, RAMAN and PTACHCINSKI, RICHARD J and BURCKART, GILBERT J and YANG, SHIN L and STARZL, THOMAS E and VAN THEIL, DAVID H (1984) The Clearance of Cyclosporine by Hemodialysis. The Journal of Clinical Pharmacology, 24 (11). 528 - 531. ISSN 0091-2700

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Abstract

<jats:p><jats:bold>Abstract: </jats:bold> The pharmacokinetics of cyclosporine were studied in five liver transplant patients when they were on and off hemodialysis. There was no significant difference in the blood clearance of cyclosporine between these two periods. Less than 1 per cent of the dose of cyclosporine was recovered in the dialysate. The mean dialysis clearance was less than 1 ml/min. This represents less than 1 per cent of the total blood clearance of cyclosporine. Dosage alterations of cyclosporine during or after hemodialysis do not appear to be necessary.</jats:p>

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
VENKATARAMANAN, RAMANrv@pitt.eduRV
PTACHCINSKI, RICHARD J
BURCKART, GILBERT J
YANG, SHIN L
STARZL, THOMAS Etes11@pitt.eduTES11
VAN THEIL, DAVID H
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 12 November 1984
Date Type: Publication
Journal or Publication Title: The Journal of Clinical Pharmacology
Volume: 24
Number: 11
Publisher: Wiley
Page Range: 528 - 531
DOI or Unique Handle: 10.1002/j.1552-4604.1984.tb02763.x
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0091-2700
Other ID: uls-drl:31735062115252, Starzl CV No. 564
Date Deposited: 08 Apr 2010 17:09
Last Modified: 22 Oct 2023 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/3950

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