Scharping, Nicole and Delgoffe, Greg
(2016)
Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity.
Vaccines, 4 (4).
ISSN 2076-393X
Abstract
When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates “metabolic checkpoints” upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME.
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Details
| Item Type: |
Article
|
| Status: |
Published |
| Creators/Authors: |
|
| Date: |
6 December 2016 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Vaccines |
| Volume: |
4 |
| Number: |
4 |
| Publisher: |
MDPI AG |
| DOI or Unique Handle: |
10.3390/vaccines4040046 |
| Schools and Programs: |
School of Medicine > Immunology |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
T cell, metabolism, immunotherapy, cancer, tumor microenvironment, metabolic checkpoints |
| ISSN: |
2076-393X |
| Official URL: |
http://dx.doi.org/10.3390/vaccines4040046 |
| Funders: |
Sidney Kimmel Foundation for Cancer Research, Skin Cancer Specialized Programs Of Research Excellence, Stand Up To Cancer and the American Association for Cancer Research |
| Article Type: |
Review |
| Date Deposited: |
04 Feb 2021 18:08 |
| Last Modified: |
04 Feb 2021 18:08 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/40225 |
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