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Extended preservation of human liver grafts with UW solution.

Todo, S and Nery, J and Yanaga, K and Podesta, L and Gordon, RD and Starzl, TE (1989) Extended preservation of human liver grafts with UW solution. JAMA, 261 (5). 711 - 714. ISSN 0098-7484

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Abstract

The fate of 185 cadaveric liver homografts preserved for four to 24 hours with University of Wisconsin (UW) solution was compared with that of 180 grafts preserved for three to 9 1/2 hours with conventional Euro-Collins solution. Although the average preservation time of the UW-preserved livers was almost twice as long as that of the Euro-Collins-preserved livers, the UW-preserved grafts survived at a higher rate; permitted equal patient survival; and had a lower rate of primary nonfunction, a reduced need for retransplantation, and a lower rate of hepatic artery thrombosis. There was no correlation between the time of preservation of UW-preserved grafts up to 24 hours and liver function abnormalities in the first postoperative week. In contrast, livers preserved with Euro-Collins solution for more than five hours had significantly increased perturbations of hepatic function tests. The potential revolutionary effect of the UW solution on liver transplantation is described herein.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Todo, S
Nery, J
Yanaga, K
Podesta, L
Gordon, RD
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 3 February 1989
Date Type: Publication
Journal or Publication Title: JAMA
Volume: 261
Number: 5
Page Range: 711 - 714
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Cause of Death, Graft Survival, Humans, Liver, Liver Transplantation, Male, Solutions, Time Factors, Tissue Preservation
ISSN: 0098-7484
Funders: NIDDK NIH HHS (R01 DK029961-19), NIADDK NIH HHS (AM 29961)
Other ID: uls-drl:31735062130855, Starzl CV No. 935
Date Deposited: 08 Apr 2010 17:15
Last Modified: 30 Oct 2017 23:56
URI: http://d-scholarship.pitt.edu/id/eprint/4321

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