Lewis, JH and Bontempo, FA and Awad, SA and Kang, YG and Kiss, JE and Ragni, MV and Spero, JA and Starzl, TE
(1989)
Liver transplantation: Intraoperative changes in coagulation factors in 100 first transplants.
Hepatology, 9 (5).
710 - 714.
ISSN 0270-9139
Abstract
Six intraoperative blood samples were obtained at intervals from each of 100 individuals undergoing their first liver transplants. The patients fell into the following diagnostic categories: postnecrotic cirrhosis 28, primary biliary cirrhosis 20, sclerosing cholangitis 19, miscellaneous diseases 14, carcinoma/neoplasia 12 and fulminant hepatitis 7. Coagulation factor values in the initial (baseline) blood samples varied by patient diagnosis. In general, all factor levels were reduced except factor VIII:C, which was increased to almost twice normal. The slight intraoperative changes in factors II, VII, IX, X, XI and XII suggested that a steady‐state relationship existed between depletion (consumption/bleeding) and repletion (transfusion, transit from extra‐ to intravascular space), even in the anhepatic state. In contrast, there were rapid and very significant falls in factor VIII and fibrinogen and a less pronounced decrease in factor V, all reaching their nadirs in early to mid‐Stage III. The cause of these coagulation changes appears to be activation of the fibrinolytic system. Copyright © 1989 American Association for the Study of Liver Diseases
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
Article
|
| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Lewis, JH | | | | | Bontempo, FA | | | | | Awad, SA | | | | | Kang, YG | | | | | Kiss, JE | jek10@pitt.edu | JEK10 | | | Ragni, MV | | | | | Spero, JA | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1989 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Hepatology |
| Volume: |
9 |
| Number: |
5 |
| Page Range: |
710 - 714 |
| DOI or Unique Handle: |
10.1002/hep.1840090509 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0270-9139 |
| Other ID: |
uls-drl:31735062110519, Starzl CV No. 1010 |
| Date Deposited: |
08 Apr 2010 17:17 |
| Last Modified: |
03 Feb 2019 04:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4396 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
 |
View Item |
![[img]](http://d-scholarship.pitt.edu/style/images/fileicons/text_plain.png)
![[feed]](/images/feed-icon-32x32.png){kind=icon}