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Effect of FK 506 on spontaneous diabetes in BB rats

Murase, N and Lieberman, I and Nalesnik, MA and Mintz, DH and Todo, S and Drash, AL and Starzl, TE (1990) Effect of FK 506 on spontaneous diabetes in BB rats. Diabetes, 39 (12). 1584 - 1586. ISSN 0012-1797

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Abstract

From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg·kg-1·day-1 (n = 19) or 2 mg·kg-1·day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, ∼75% of the rats that were diabetes free at 120 days remained so.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Murase, N
Lieberman, I
Nalesnik, MAnalesnik@pitt.eduNALESNIK
Mintz, DH
Todo, S
Drash, AL
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Diabetes
Volume: 39
Number: 12
Page Range: 1584 - 1586
DOI or Unique Handle: 10.2337/diab.39.12.1584
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0012-1797
Other ID: uls-drl:31735062116847, Starzl CV No. 1131
Date Deposited: 08 Apr 2010 17:19
Last Modified: 19 Jun 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/4517

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