Abu-Elmagd, K and Fung, JJ and Alessiani, M and Jain, A and Venkataramanan, R and Warty, VS and Takaya, S and Todo, S and Shannon, WD and Starzl, TE
(1991)
The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver.
Transplantation, 52 (1).
71 - 77.
ISSN 0041-1337
Abstract
Plasma FK506 was studied in 49 liver, 13 heart, 3 double-lung or heart-lung, and 21 kidney recipients. The levels were correlated with the drug doses used, kidney function, and liver function. In all varieties of recipients, there was an early rise in the FK506 plasma levels that occurred at the time of intravenous administration of the drug. At the same time or shortly after, there were increases in serum creatinine that were transitory except in liver recipients with continuing suboptimal graft function. The quality of hepatic function dominated all aspects of FK506 management in the liver recipients. Those who received well-functioning grafts could be given about the same drug doses as recipients of kidneys and the thoracic organs. Liver recipients with defective grafts had astronomical rises in plasma FK506, a high incidence of renal failure, and probably increased neurotoxicity. In kidney transplant recipients, the FK506 plasma levels and doses were essentially the same in patients with prompt versus delayed renal function. These studies have highlighted the necessity, first, of close pharmacologic monitoring of patients who are given FK506 in the presence of abnormal liver function, and second, of using smaller intravenous induction doses than in past practice. © 1991 by Williams & Wilkins.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Abu-Elmagd, K | | | | | Fung, JJ | | | | | Alessiani, M | | | | | Jain, A | | | | | Venkataramanan, R | rv@pitt.edu | RV | | | Warty, VS | | | | | Takaya, S | | | | | Todo, S | | | | | Shannon, WD | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1991 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
52 |
| Number: |
1 |
| Page Range: |
71 - 77 |
| DOI or Unique Handle: |
10.1097/00007890-199107000-00015 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062117555, Starzl CV No. 1203 |
| Date Deposited: |
08 Apr 2010 17:20 |
| Last Modified: |
02 Feb 2019 13:57 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4589 |
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