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Renal transplantation at the University of Pittsburgh: the impact of FK506.

Shapiro, R and Jordan, M and Scantlebury, VP and Vivas, C and Gritsch, HA and Rao, AS and Trucco, M and Zeevi, A and Demetris, AJ and Randhawa, P (1994) Renal transplantation at the University of Pittsburgh: the impact of FK506. Clinical transplants. 229 - 236. ISSN 0890-9016

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Abstract

1. In an unselected adult renal transplant population, FK506 as the primary immunosuppressive agent yielded one- and 2-year actuarial patient survival rates of 95% and 93% and one- and 2-year actuarial graft survival rates of 89% and 83%, respectively. Forty-nine percent of successfully transplanted patients were weaned off steroids. 2. In pediatric renal transplant patients, FK506 has been associated with 100% one- and 3-year actuarial patient survival rates and 98% and 85% one- and 3-year actuarial graft survival rates, respectively. Sixty-two percent of successfully transplanted patients were taken off prednisone, with dramatic improvements in height. 3. FK506 has been used successfully in rescuing 70-74% of adult or pediatric renal transplant patients with an acute rejection that failed conventional therapy. 4. Kidney/bone marrow transplantation under FK506 therapy has been successfully performed without graft-versus-host disease and with routine augmentation of chimerism. 5. The side effects of FK506 included nephrotoxicity, neurotoxicity, and diabetogenicity; they were comparable to those seen with CsA. 6. FK506 is an important new addition to the immunosuppressive armamentarium in renal transplant patients.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Shapiro, R
Jordan, M
Scantlebury, VP
Vivas, C
Gritsch, HA
Rao, AS
Trucco, Mmnt@pitt.eduMNT
Zeevi, A
Demetris, AJ
Randhawa, P
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Clinical transplants
Page Range: 229 - 236
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0890-9016
Other ID: uls-drl:31735062126531, Starzl CV No. 1776
PubMed ID: 7547544
Date Deposited: 08 Apr 2010 17:30
Last Modified: 18 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/5162

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