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Is rejection a diffuse or localized process in small-bowel transplantation?

Gurakar, A and Fagiuoli, S and Hassanein, T and Wright, HI and Balkan, M and Frezza, E and Todo, S and Starzl, TE and Van Thiel, DH (1994) Is rejection a diffuse or localized process in small-bowel transplantation? Surgical Endoscopy, 8 (7). 762 - 764. ISSN 0930-2794

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Abstract

Utilization of endoscopy to both visualize and selectively biopsy an intestinal allograft has become the standard for early recognition and treatment of intestinal allograft rejection. Despite the widespread acceptance of the need for selective mucosal biopsies, it has not been shown that the histological features of intestinal allograft rejection are either localized or occur as part of a more diffuse phenomenon within a tubular allograft. To resolve these issues, 88 ileoscopies were performed in 12 small-bowel allograft recipients and mucosal biopsy samples were obtained at 5, 10, and 15 cm, respectively, from the ileal stoma. Each mucosal biopsy was labeled, processed, and evaluated individually for the presence and severity of any evidence for allograft rejection. The data obtained suggest that intestinal allograft rejection is a diffuse process, and biopsies obtained randomly from an ileal graft are likely to demonstrate evidence of allograft rejection when such is present. © 1994 Springer-Verlag New York Inc.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gurakar, A
Fagiuoli, S
Hassanein, T
Wright, HI
Balkan, M
Frezza, E
Todo, S
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 July 1994
Date Type: Publication
Journal or Publication Title: Surgical Endoscopy
Volume: 8
Number: 7
Page Range: 762 - 764
DOI or Unique Handle: 10.1007/bf00593436
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0930-2794
Other ID: uls-drl:31735062126648, Starzl CV No. 1810
Date Deposited: 08 Apr 2010 17:30
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/5196

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