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Lack of susceptibility of baboons to infection with hepatitis B virus

Michaels, MG and Lanford, R and Demetris, AJ and Chavez, D and Brasky, K and Fung, J and Starzl, TE (1996) Lack of susceptibility of baboons to infection with hepatitis B virus. Transplantation, 61 (3). 350 - 351. ISSN 0041-1337

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Abstract

Historically, hepatitis B virus (HBV) has been considered species specific and unable to infect baboons. Based on this premise, two patients with HBV end-stage liver disease underwent baboon liver xenotransplantation. To study whether baboons are susceptible to HBV infection, four baboons (two receiving immunosuppressive therapy) were inoculated with HBV. Animals were followed for 6 months: clinical examinations and biochemical studies were normal, hepatitis B surface antigen and hepatitis B core antigen staining of biopsies was negative, and HBV serology remained negative. HBV polymerase chain reaction was transiently positive in one animal, which most likely reflects the initial inoculation. This pilot study corroborates historical evidence and beliefs that baboons are resistant to HBV.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Michaels, MG
Lanford, R
Demetris, AJ
Chavez, D
Brasky, K
Fung, J
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 15 February 1996
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 61
Number: 3
Page Range: 350 - 351
DOI or Unique Handle: 10.1097/00007890-199602150-00002
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062133388, Starzl CV No. 1874
Date Deposited: 08 Apr 2010 17:32
Last Modified: 07 Jul 2020 09:55
URI: http://d-scholarship.pitt.edu/id/eprint/5260

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