Shapiro, R and Vivas, C and Scantlebury, VP and Jordan, ML and Gritsch, HA and Neugarten, J and Mccauley, J and Randhawa, P and Irish, W and Fung, JJ and Hakala, T and Simmons, RL and Starzl, TE
(1996)
"Suboptimal" kidney donors: The experience with tacrolimus-based immunosuppression.
Transplantation, 62 (9).
1242 - 1246.
ISSN 0041-1337
Abstract
Female, pediatric, and older donors have been associated with inferior graft survival after renal transplantation. We analyzed these three subgroups in 397 patients receiving tacrolimus-based immunosuppression. There were no differences in recipient age, incidence of retransplantation, or percentage of sensitized patients. Female donors, compared with male donors, were associated with comparable 1- and 3-year patient survival rates (96% and 93% vs. 95% and 92%, respectively) and comparable 1- and 3-year graft survival rates (90% and 80% vs. 88% and 81%, respectively). Renal function was also similar. Recipients of pediatric en bloc kidneys, when compared with recipients of other cadaveric kidneys, also had comparable 1- and 3-year patient survival rates (94% and 94% vs. 95% and 91%, respectively) and comparable 1- and 3-year graft survival rates (84% and 84% vs. 89% and 79%, respectively). Renal function was better in recipients of en bloc kidneys, with a mean serum creatinine level of 1.4±1.8 mg/dl vs. 2.0±1.5 mg/dl (P=0.01). In contrast to the first two subgroups, donors over 60 years of age, when compared with donors under 60 years of age, were associated with worse 1- and 3-year patient survival rates (88% and 80% vs. 96% and 94%, respectively; P<0.03) and worse 1- and 3-year graft survival rates (74% and 62% vs. 91% and 83%, respectively; P<0.0001). Renal function was worse in the older donor group, with a serum creatinine level of 2.7±1.2 mg/ml vs. 1.9±1.5 mg/dl (P=0.01). We conclude that, under tacrolimus-based immunosuppression, kidneys from female or very young pediatric donors are not associated with adverse outcomes, whereas kidneys from donors over 60 years of age are associated with inferior outcomes.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Shapiro, R | | | | | Vivas, C | | | | | Scantlebury, VP | | | | | Jordan, ML | | | | | Gritsch, HA | | | | | Neugarten, J | | | | | Mccauley, J | | | | | Randhawa, P | | | | | Irish, W | | | | | Fung, JJ | | | | | Hakala, T | | | | | Simmons, RL | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
15 November 1996 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
62 |
| Number: |
9 |
| Page Range: |
1242 - 1246 |
| DOI or Unique Handle: |
10.1097/00007890-199611150-00010 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062133412, Starzl CV No. 1877 |
| Date Deposited: |
08 Apr 2010 17:32 |
| Last Modified: |
04 Feb 2019 15:58 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5263 |
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