Macala, Megan K
(2007)
Exploration of Bis-amino Acid Scaffolds Designed to Self Assemble.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Based on theoretical models scaffold 13 was predicted to self assemble through intermolecular hydrogen bonds. The synthesis of scaffold 13 was successfully synthesized using standard Fmoc Solid Phase Peptide Synthesis. Connectivity was confirmed through full structural characterization. Scaffold 13 was probed for its ability to self-assemble in DMSOd6 in the presence of 0.2 percent TFA. Our hypothesis for self-assembly of scaffold 13 was not supported under any of the conditions explored. ROESY correlations failed to indicate self-assembly between interacting scaffolds and a variable temperature NMR study at three separate concentrations also failed to provide evidence of self-assembly.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
14 June 2007 |
| Date Type: |
Completion |
| Defense Date: |
26 February 2007 |
| Approval Date: |
14 June 2007 |
| Submission Date: |
27 February 2007 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
bis-amino acids; macromolecule; molecular scaffolds; oliogmer; self assemble |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-02272007-153543/, etd-02272007-153543 |
| Date Deposited: |
10 Nov 2011 19:31 |
| Last Modified: |
15 Nov 2016 13:36 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/6413 |
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