Hund, Samuel J.
(2006)
HEMODYNAMIC DESIGN OPTIMIZATION OF A VENTRICULAR CANNULA:EVALUATION AND IMPLEMENTATION OF OBJECTIVE FUNCTIONS.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Shape optimization has been used for decades to improve the aerodynamic performance of automobiles and aircraft. The application of this technology to blood-wetted medical devices have been limited, in part, due to the ambiguity of hemodynamic variables associated with biocompatibility - specifically hemolysis, platelet activation, and thrombus formation. This study undertook a systematic evaluation of several objective functions derived directly from the flow field. We specifically focused on the optimization of a two-dimensional blood conduit (cannula) by allowing free variation of the centerline and cross-sectional area. The flow was simulated using computational fluid dynamics (CFD) at a nominal flow rate of 6 lpm and boundary conditions consistent with an abdominally positioned left-ventricular-assist device (LVAD). The objectives were evaluated both locally and globally. The results demonstrated similarities between four of the functions: vorticity, viscous dissipation, principal shear stress, and power-law (PL) blood damage models based on shear history. Of the functions analyzed, those found to be most indicative of flow separation and clearance were flow deviation index and the Peclet Number. The conclusions from these studies will be applied to ongoing development of algorithms for optimizing the flow path of rotary blood pumps, cannula, and other blood contacting devices.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
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| ETD Committee: |
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| Date: |
2 June 2006 |
| Date Type: |
Completion |
| Defense Date: |
8 March 2006 |
| Approval Date: |
2 June 2006 |
| Submission Date: |
17 March 2006 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Bioengineering |
| Degree: |
MSBeng - Master of Science in Bioengineering |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
computational fluid dynamics; hemolysis; optimization; thrombosis |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-03172006-152030/, etd-03172006-152030 |
| Date Deposited: |
10 Nov 2011 19:32 |
| Last Modified: |
15 Nov 2016 13:37 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/6520 |
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