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Developmental Changes in Brain Function Underlying the Influence of Reward Processing on Inhibitory Control

Padmanabhan, Aarthi (2011) Developmental Changes in Brain Function Underlying the Influence of Reward Processing on Inhibitory Control. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Adolescence is a period marked by changes in motivational and cognitive brain systems. However, the development of the interactions between reward and cognitive control processing are just beginning to be understood. Using event-related functional neuroimaging and an incentive modulated antisaccade task, we compared blood-oxygen level dependent activity underlying motivated response inhibition in children, adolescents, and adults. Behaviorally, children and adolescents performed significantly worse than adults during neutral trials. However, children and adolescents showed significant performance increases during reward trials. Adults showed no performance changes across conditions. fMRI results demonstrated that all groups recruited a similar circuitry to support task performance, including regions typically associated with rewards (striatum and orbital frontal cortex), and regions known to be involved in inhibitory control (putative frontal and supplementary eye fields, and posterior parietal cortex, and prefrontal loci). During rewarded trials adolescents showed increased activity in striatal regions, while adults demonstrated heightened activation in the OFC relative to children and adolescents. Children showed greater reliance on prefrontal executive regions that may be related to increased effort inhibiting responses. Overall, these results indicate that response inhibition is enhanced with reward contingencies over development. Adolescents' heightened response in striatal regions may be one factor contributing to reward-biased decision making and perhaps risk taking behavior.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Padmanabhan, Aarthipadmanabhana@upmc.edu
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairLuna, Beatrizlunab@upmc.eduLUNA
Committee MemberFiez, Juliefiez@pitt.eduFIEZ
Committee MemberWheeler, Markwheeler.me@gmail.com
Date: 6 June 2011
Date Type: Completion
Defense Date: 18 August 2010
Approval Date: 6 June 2011
Submission Date: 20 April 2011
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: adolescence; antisaccade; fMRI; inhibitory control; reward
Other ID: http://etd.library.pitt.edu/ETD/available/etd-04202011-135629/, etd-04202011-135629
Date Deposited: 10 Nov 2011 19:39
Last Modified: 19 Dec 2016 14:35
URI: http://d-scholarship.pitt.edu/id/eprint/7392

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