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Causation in the Nature-Nurture Debate: The Case of Genotype-Environment Interaction

Tabery, James Gregory (2007) Causation in the Nature-Nurture Debate: The Case of Genotype-Environment Interaction. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

I attempt to resolve an aspect of the nature-nurture debate. Consider a typical nature-nurture question: Why do some individuals develop a complex trait such as depression, while others do not? This question incorporates an etiological query about the causal mechanisms responsible for the individual development of depression; it also incorporates an etiological query about the causes of variation responsible for individual differences in the occurrence of depression. Scientists in the developmental research tradition of biology investigate the former; scientists in the biometric research tradition of biology investigate the latter. So what is the relationship?The developmental and biometric research traditions, I argue, are united in their joint effort to elucidate what I call difference mechanisms. Difference mechanisms are regular causal mechanisms made up of difference-making variables that take different values in the natural world. On this model, individual differences are the effect of difference-makers in development that take different values in the natural world. I apply this model to the case of genotype-environment interaction (or G×E), showing that there have actually been two separate concepts of G×E: a biometric concept (or G×EB) and a developmental concept (or G×ED). These concepts also may be integrated via the difference mechanisms model: G×E results from the interdependence of difference-makers in development that take different values in the natural world.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tabery, James Gregoryjimtabery@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee CoChairGriffiths, Paul Epauleg@bigpond.com
Committee CoChairMitchell, Sandrasmitchel@pitt.eduSMITCHEL
Committee MemberSchaffner, Kennethkfs@pitt.eduKFS
Committee MemberPogue-Geile, Michaelmfpg@pitt.eduMFPG
Committee MemberOlby, Robertolbyr@comcast.net
Date: 20 September 2007
Date Type: Completion
Defense Date: 17 July 2007
Approval Date: 20 September 2007
Submission Date: 23 July 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > History and Philosophy of Science
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Causation; Difference-Makers; Eugenics; Gene-Environment Interaction; History of Genetics; IQ Controversy; Lancelot Hogben; Mechanism; R.A. Fisher; Race; Explanation; Philosophy of Science
Other ID: http://etd.library.pitt.edu/ETD/available/etd-07232007-121636/, etd-07232007-121636
Date Deposited: 10 Nov 2011 19:53
Last Modified: 15 Nov 2016 13:46
URI: http://d-scholarship.pitt.edu/id/eprint/8535

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