Dukes, Joe Warren
(2005)
Gating and Permeation of Ion Channels.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Recent crystal structures of ClC chloride channels have led to a proposed fast-gating mechanism that couples ion permeation to ion channel gating. This proposed mechanism is studied by pushing the amino acid E148 of StClC out of the path of the proposed permeation path. The resulting structure produces an open state that is similar to the mutant EcClC E148Q structure, a proposed open structure of ClC-type channels. Due to the interaction of the fast-gate with permeating ions, a hybrid methodology is proposed for explicitly simulating the interaction of protein fluctuations with permeating ions. This methodology is used for two model systems and compared to single-ion Potential of Mean Force permeation models methodologies.
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Details
Item Type: |
University of Pittsburgh ETD
|
Status: |
Unpublished |
Creators/Authors: |
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ETD Committee: |
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Date: |
3 February 2005 |
Date Type: |
Completion |
Defense Date: |
17 November 2004 |
Approval Date: |
3 February 2005 |
Submission Date: |
6 December 2004 |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Institution: |
University of Pittsburgh |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Degree: |
MS - Master of Science |
Thesis Type: |
Master's Thesis |
Refereed: |
Yes |
Uncontrolled Keywords: |
gating; ion channels; permeation |
Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-12062004-115051/, etd-12062004-115051 |
Date Deposited: |
10 Nov 2011 20:08 |
Last Modified: |
15 Nov 2016 13:53 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/10085 |
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