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Clinical studies on cytokines in sepsis: role of serum cytokines in the development of multiple-systems organ failure.

Pinsky, MR (1994) Clinical studies on cytokines in sepsis: role of serum cytokines in the development of multiple-systems organ failure. Nephrol Dial Transplant, 9 Supp. 94 - 98. ISSN 0931-0509

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Abstract

The universal finding of a persistently elevated serum TNF level after 12 h in patients who go on to develop MSOF and die suggests that factors other than peak intensity of intravascular proinflammatory response determine survival. The persistence of elevated levels of TNF in the serum of patients who progress to MSOF suggests an aetiological relationship between continual activation of the immune response and remote organ dysfunction in critically ill patients.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1994
Date Type: Publication
Journal or Publication Title: Nephrol Dial Transplant
Volume: 9 Supp
Page Range: 94 - 98
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
Uncontrolled Keywords: Critical Illness, Cytokines, Humans, Inflammation, Liver Cirrhosis, Multiple Organ Failure, Sepsis, Shock, Septic
ISSN: 0931-0509
PubMed ID: 7800275
Date Deposited: 05 Mar 2012 17:16
Last Modified: 14 Mar 2021 08:56
URI: http://d-scholarship.pitt.edu/id/eprint/11177

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