Hale, James
(2012)
Implementation of Catalytic, Asymmetric Technology Toward the Total Synthesis of Apoptolidin C.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
The total synthesis of apoptolidin C (3), a highly selective cytotoxic macrolide, has been under investigation in our lab. Work completed includes the synthesis of the C1-C11 fragment 29, the macrocyclic core 3b, and the disaccharide subunit 31. These goals have been realized utilizing catalytic, asymmetric reaction methodology including the acyl halide-aldehyde cyclocondensation (AAC) and proline catalyzed dimerization of simple aldehyde starting materials 33-38.
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Details
Item Type: |
University of Pittsburgh ETD
|
Status: |
Unpublished |
Creators/Authors: |
|
ETD Committee: |
|
Date: |
18 June 2012 |
Date Type: |
Publication |
Defense Date: |
30 March 2012 |
Approval Date: |
18 June 2012 |
Submission Date: |
4 April 2012 |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Number of Pages: |
178 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Degree: |
PhD - Doctor of Philosophy |
Thesis Type: |
Doctoral Dissertation |
Refereed: |
Yes |
Uncontrolled Keywords: |
total synthesis, organic chemistry, apoptolidin c, aac, acyl halide-aldehyde cyclocondensation |
Date Deposited: |
18 Jun 2012 17:59 |
Last Modified: |
15 Nov 2016 13:57 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/11681 |
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