Maher, AC and Akhtar, M and Vockley, J and Tarnopolsky, MA
(2010)
Women have higher protein content of β-oxidation enzymes in skeletal muscle than men.
PLoS ONE, 5 (8).
Abstract
It is well recognized that compared with men, women have better ultra-endurance capacity, oxidize more fat during endurance exercise, and are more resistant to fat oxidation defects i.e. diet-induced insulin resistance. Several groups have shown that the mRNA and protein transcribed and translated from genes related to transport of fatty acids into the muscle are greater in women than men; however, the mechanism(s) for the observed sex differences in fat oxidation remains to be determined. Muscle biopsies from the vastus lateralis were obtained from moderately active men (N = 12) and women (N = 11) at rest to examine mRNA and protein content of genes involved in lipid oxidation. Our results show that women have significantly higher protein content for tri-functional protein alpha (TFPα), very long chain acyl-CoA dehydrogenase (VLCAD), and medium chain acyl-CoA dehydrogenase (MCAD) (P<0.05). There was no significant sex difference in the expression of short-chain hydroxyacyl-CoA dehydrogenase (SCHAD), or peroxisome proliferator activated receptor alpha (PPARa), or PPARc, genes potentially involved in the transcriptional regulation of lipid metabolism. In conclusion, women have more protein content of the major enzymes involved in long and medium chain fatty acid oxidation which could account for the observed differences in fat oxidation during exercise. © 2010 Maher et al.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
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Contributors: |
Contribution | Contributors Name | Email | Pitt Username | ORCID  |
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Editor | Polymenis, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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Date: |
15 October 2010 |
Date Type: |
Publication |
Journal or Publication Title: |
PLoS ONE |
Volume: |
5 |
Number: |
8 |
DOI or Unique Handle: |
10.1371/journal.pone.0012025 |
Schools and Programs: |
School of Public Health > Human Genetics |
Refereed: |
Yes |
MeSH Headings: |
Acyl-CoA Dehydrogenase--genetics; Acyl-CoA Dehydrogenase--metabolism; Female; Gene Expression Regulation, Enzymologic; Humans; Lipid Metabolism--genetics; Male; Muscle Proteins--metabolism; Muscle, Skeletal--enzymology; Muscle, Skeletal--metabolism; Oxidation-Reduction; PPAR alpha--metabolism; PPAR gamma--metabolism; RNA, Messenger--genetics; RNA, Messenger--metabolism; Sex Characteristics; Young Adult |
Other ID: |
NLM PMC2917369 |
PubMed Central ID: |
PMC2917369 |
PubMed ID: |
20700461 |
Date Deposited: |
15 Aug 2012 18:13 |
Last Modified: |
04 Feb 2023 11:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/13393 |
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