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Effect of smoking on circulating angiogenic factors in high risk pregnancies

Jeyabalan, A and Powers, RW and Clifton, RG and van Dorsten, P and Hauth, JC and Klebanoff, MA and Lindheimer, MD and Sibai, B and Landon, M and Miodovnik, M (2010) Effect of smoking on circulating angiogenic factors in high risk pregnancies. PLoS ONE, 5 (10).

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Abstract

Objective: Changes in maternal concentrations of the anti-angiogenic factors, soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng), and the pro-angiogenic placental growth factor (PlGF) precede the development of preeclampsia in healthy women. The risk of preeclampsia is reduced in women who smoke during pregnancy. The objective of this study was to investigate whether smoking affects concentrations of angiogenic factors (sFlt1, PlGF, and sEng) in women at high risk for developing preeclampsia. Study Design: We performed a secondary analysis of serum samples from 993 high-risk women (chronic hypertension, diabetes, multifetal gestation, and previous preeclampsia) in a preeclampsia prevention trial. sFlt1, sEng and PlGF were measured in serum samples obtained at study entry, which was prior to initiation of aspirin (median 19.0 weeks' [interquartile range of 16.0-22.6 weeks']). Smoking status was determined by self-report. Results: sFlt1 was not significantly different in smokers from any high-risk groups compared to their nonsmoking counterparts. PlGF was higher among smokers compared to nonsmokers among diabetic women (142.7 [77.4-337.3] vs 95.9 [48.5-180.7] pg/ml, p = 0.005) and women with a history of preeclampsia (252.2 [137.1-486.0] vs 152.2 [73.6-253.7] pg/ml, p = 0.001). sEng was lower in smokers with multifetal gestations (5.8 [4.6-6.5] vs 6.8 [5.5-8.7] ng/ml, p = 0.002) and trended lower among smokers with diabetes (4.9 [3.8-5.6] vs 5.3 [4.3-6.3] ng/ml, p = 0.05). Smoking was not associated with a lower incidence of preeclampsia in any of these groups. Conclusions: In certain high-risk groups, smoking is associated with changes in the concentrations of these factors towards a pro-angiogenic direction during early pregnancy; however, there was no apparent association between smoking and the development of preeclampsia in our cohort.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Jeyabalan, Aarunj@pitt.eduARUNJ
Powers, RWpowersr@pitt.eduPOWERSR
Clifton, RG
van Dorsten, P
Hauth, JC
Klebanoff, MA
Lindheimer, MD
Sibai, B
Landon, M
Miodovnik, M
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
InvestigatorCaritis, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRoberts, J MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKuller, JUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCotroneo, MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKamon, TUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMercer, BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRamsey, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorPaul, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRabello, YUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMcCart, DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMueller, EUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorGoldenberg, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCopper, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSorokin, YUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorNorman, GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMillinder, AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorChristmas, J TUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMcCoy, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorElder, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorElder, NUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCarter, BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorPemberton, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorThurnau, GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeier, AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMinton, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeis, PUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSwain, MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMoawad, A HUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorJones, PUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorIams, J DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeadows, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBrenner, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCollins, BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorNewman, R BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCarter, S GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRomero, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSabo, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorThom, EUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBain, R PUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMacPherson, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorJohnson, DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorFischer, M LUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMcNellis, DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSpong, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCatz, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorYaffe, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 17 November 2010
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 5
Number: 10
DOI or Unique Handle: 10.1371/journal.pone.0013270
Schools and Programs: School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
MeSH Headings: Adult; Angiogenesis Inducing Agents--blood; Female; Humans; Pregnancy; Pregnancy, High-Risk; Smoking--blood
Other ID: NLM PMC2953508
PubMed Central ID: PMC2953508
PubMed ID: 20967275
Date Deposited: 23 Aug 2012 16:01
Last Modified: 04 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/13732

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