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Soluble fms-Like Tyrosine Kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies

Powers, RW and Jeyabalan, A and Clifton, RG and van Dorsten, P and Hauth, JC and Klebanoff, MA and Lindheimer, MD and Sibai, B and Landon, M and Miodovnik, M (2010) Soluble fms-Like Tyrosine Kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS ONE, 5 (10).

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Abstract

Background: Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women. The objective of this study was to investigate whether similar changes can be detected in pregnant women at high-risk to develop the syndrome. Methods: This study is a secondary analysis of the NICHD MFMU trial of aspirin to prevent preeclampsia in high-risk pregnancies. Serum samples were available from 194 women with pre-existing diabetes, 313 with chronic hypertension, 234 with multifetal gestation, and 252 with a history of preeclampsia in a previous pregnancy. Samples collected across pregnancy were analyzed in a blinded fashion for sFlt1, sEng and PlGF. Results: The odds of developing preeclampsia were significantly increased among women with multiple fetuses for each 2- fold elevation in sFlt1, sEng and the ratio of angiogenic factors (e.g. OR 2.18, 95% CI 1.46-3.32), and significantly decreased for each 2-fold elevation in circulating PlGF (OR 0.50, 95% CI 0.30-0.82) between 7 and 26 weeks' gestation. Cross-sectional analysis of the angiogenic factors across gestation showed significant differences during the third trimester in women who develop preeclampsia compared with appropriate controls in all high-risk groups. However, when data were examined in relation to the gestational week when preeclampsia was diagnosed only sFlt1 was significantly higher 2 to 5 weeks before the clinical onset of preeclampsia and only in women with previous preeclampsia. Conclusions: The pattern of elevated concentrations of sFlt1 and sEng, and low PlGF in high-risk pregnant subjects who develop preeclampsia is similar to that reported in low-risk pregnant women. However, differences in these factors among high-risk women who do and do not develop preeclampsia are modest, and do not appear to be clinically useful predictors in these high-risk pregnant women.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Powers, RWpowersr@pitt.eduPOWERSR
Jeyabalan, Aarunj@pitt.eduARUNJ
Clifton, RG
van Dorsten, P
Hauth, JC
Klebanoff, MA
Lindheimer, MD
Sibai, B
Landon, M
Miodovnik, M
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
InvestigatorCaritis, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRoberts, J MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKuller, JUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCotroneo, MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKamon, TUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMercer, BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRamsey, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorPaul, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRabello, YUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMcCart, DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMueller, EUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorGoldenberg, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCopper, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSorokin, YUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorNorman, GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMillinder, AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorChristmas, J TUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMcCoy, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorElder, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorElder, NUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCarter, BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorPemberton, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorThurnau, GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeier, AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMinton, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeis, PUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSwain, MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMoawad, A HUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorJones, PUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorIams, J DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeadows, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBrenner, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCollins, BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorNewman, R BUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCarter, S GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRomero, RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSabo, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorThom, EUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBain, R PUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMacPherson, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorJohnson, DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorFischer, M LUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMcNellis, DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSpong, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCatz, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorYaffe, SUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 17 November 2010
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 5
Number: 10
DOI or Unique Handle: 10.1371/journal.pone.0013263
Schools and Programs: School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
MeSH Headings: Adult; Angiogenesis Inducing Agents--blood; Antigens, CD--blood; Female; Humans; Pre-Eclampsia--blood; Pre-Eclampsia--diagnosis; Pregnancy; Pregnancy Proteins--blood; Receptor, Macrophage Colony-Stimulating Factor--blood; Receptors, Cell Surface--blood
Other ID: NLM PMC2952583
PubMed Central ID: PMC2952583
PubMed ID: 20948996
Date Deposited: 23 Aug 2012 16:01
Last Modified: 04 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/13733

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