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Nocturia, sleep-disordered breathing, and cardiovascular morbidity in a community-based cohort

Parthasarathy, S and Fitzgerald, MP and Goodwin, JL and Unruh, M and Guerra, S and Quan, SF (2012) Nocturia, sleep-disordered breathing, and cardiovascular morbidity in a community-based cohort. PLoS ONE, 7 (2).

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Abstract

Background: Nocturia has been independently associated with cardiovascular morbidity and all-cause mortality, but such studies did not adjust for sleep-disordered breathing (SDB), which may have mediated such a relationship. Our aims were to determine whether an association between nocturia and cardiovascular morbidity exists that is independent of SDB. We also determined whether nocturia is independently associated with SDB. Methodology/Principal Findings: In order to accomplish these aims we performed a cross-sectional analysis of the Sleep Heart Health Study that contained information regarding SDB, nocturia, and cardiovascular morbidity in a middle-age to elderly community-based population. In 6342 participants (age 63±11 [SD] years, 53% women), after adjusting for known confounders such as age, body mass index, diuretic use, diabetes mellitus, alpha-blocker use, nocturia was independently associated with SDB (measured as Apnea Hypopnea index >15 per hour; OR 1.3; 95%CI, 1.2-1.5). After adjusting for SDB and other known confounders, nocturia was independently associated with prevalent hypertension (OR 1.23; 95%CI 1.08-1.40; P = 0.002), cardiovascular disease (OR 1.26; 95%CI 1.05-1.52; P = 0.02) and stroke (OR 1.62; 95%CI 1.14-2.30; P = 0.007). Moreover, nocturia was also associated with adverse objective alterations of sleep as measured by polysomnography and self-reported excessive daytime sleepiness (P<0.05). Conclusions/Significance: Nocturia is independently associated with sleep-disordered breathing. After adjusting for SDB, there remained an association between nocturia and cardiovascular morbidity. Such results support screening for SDB in patients with nocturia, but the mechanisms underlying the relationship between nocturia and cardiovascular morbidity requires further study. MeSH terms: Nocturia, sleep-disordered breathing, obstructive sleep apnea, sleep apnea, polysomnography, hypertension.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Parthasarathy, S
Fitzgerald, MP
Goodwin, JL
Unruh, M
Guerra, S
Quan, SF
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorBayer, AntonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 6 February 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 2
DOI or Unique Handle: 10.1371/journal.pone.0030969
Refereed: Yes
MeSH Headings: Aged; Cardiovascular Diseases--epidemiology; Cardiovascular Diseases--mortality; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nocturia--epidemiology; Nocturia--physiopathology; Polysomnography; Sleep Apnea Syndromes--epidemiology; Sleep Apnea Syndromes--physiopathology
Other ID: NLM PMC3273490
PubMed Central ID: PMC3273490
PubMed ID: 22328924
Date Deposited: 12 Sep 2012 21:45
Last Modified: 04 Feb 2019 16:55
URI: http://d-scholarship.pitt.edu/id/eprint/14017

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