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Factors associated with attrition of African Americans during the recruitment phase of a clinical trial examining adherence among individuals with rheumatoid arthritis

Dunbar-Jacob, J and Holmes, JL and Sereika, S and Kwoh, CK and Burke, LE and Starz, TW and McCall, M and Foley, SM (2004) Factors associated with attrition of African Americans during the recruitment phase of a clinical trial examining adherence among individuals with rheumatoid arthritis. Arthritis Care and Research, 51 (3). 422 - 428. ISSN 2151-4658

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Objective. To examine factors contributing to the loss of potential minority participants in a study of medication adherence among rheumatoid arthritis patients. Methods. Chi-square statistics were used to test for differences in refusal/ineligibility by race and site at 4 screening points (initial eligibility review, initial patient contact, adherence screening, and informed consent). Differences in criteria-specific risks for exclusion at initial eligibility review were examined across 4 sites by race. Odds ratios (95% confidence intervals) were estimated if differences were significant. Multivariate logistic regression was used to examine sociodemographic factors associated with the probability for ineligibility at the initial eligibility review. Stated reasons for refusal were qualitatively quantified. Results. A greater percentage of African Americans were lost at every screening point when compared with whites, but only the difference at the initial eligibility review was statistically significant. Conclusion. Factors associated with attrition included selection of area medical sites, research design issues, comorbid conditions, alcohol abuse, and being younger, unmarried, African American, and male.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Dunbar-Jacob, Jdunbar@pitt.eduDUNBAR
Holmes, JL
Sereika, Sssereika@pitt.eduSSEREIKA
Kwoh, CK
Burke, LElbu100@pitt.eduLBU100
Starz, TW
McCall, Mmccallm@pitt.eduMCCALLM
Foley, SM
Date: 15 June 2004
Date Type: Publication
Journal or Publication Title: Arthritis Care and Research
Volume: 51
Number: 3
Page Range: 422 - 428
DOI or Unique Handle: 10.1002/art.20411
Schools and Programs: School of Nursing > Nursing
Refereed: Yes
ISSN: 2151-4658
Article Type: Review
MeSH Headings: Adult; African Americans--statistics & numerical data; Aged; Aged, 80 and over; Antirheumatic Agents--therapeutic use; Arthritis, Rheumatoid--drug therapy; Arthritis, Rheumatoid--psychology; Arthritis, Rheumatoid--therapy; Chi-Square Distribution; Clinical Trials as Topic--statistics & numerical data; Cognitive Therapy; European Continental Ancestry Group--statistics & numerical data; Female; Humans; Informed Consent; Logistic Models; Male; Middle Aged; Odds Ratio; Patient Compliance; Patient Dropouts--statistics & numerical data; Personnel Selection; Sex Ratio
PubMed ID: 15188328
Date Deposited: 20 Sep 2012 20:40
Last Modified: 19 Jul 2020 12:55


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