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Characterization of a Mycobacterium Smegmatis Mutant that is Simultaneously Resistant to D-Cycloserine and Vancomycin.

Peteroy, M and Severin, A and Zhao, F and Rosner, D and Lopatin, U and Scherman, H and Belanger, A and Harvey, B and Hatfull, Graham F and Brennan, PJ and Connell, ND (2000) Characterization of a Mycobacterium Smegmatis Mutant that is Simultaneously Resistant to D-Cycloserine and Vancomycin. Antimicrobial agents and chemotherapy, 44 (6). 1701 - 1704. ISSN 0066-4804

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Abstract

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Peteroy, M
Severin, A
Zhao, F
Rosner, D
Lopatin, U
Scherman, H
Belanger, A
Harvey, B
Hatfull, Graham Fgfh@pitt.eduGFH
Brennan, PJ
Connell, ND
Date: June 2000
Date Type: Publication
Journal or Publication Title: Antimicrobial agents and chemotherapy
Volume: 44
Number: 6
Publisher: American Society for Microbiology
Page Range: 1701 - 1704
DOI or Unique Handle: 10.1128/aac.44.6.17-1-1704.2000
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0066-4804
Article Type: Research Article
MeSH Headings: Amino Acid Sequence; Cycloserine--pharmacology; Drug Resistance, Microbial; Molecular Sequence Data; Mutation; Mycobacterium smegmatis--drug effects; Mycobacterium smegmatis--genetics; Sequence Alignment; Vancomycin--pharmacology; Vancomycin Resistance
Other ID: NLM PMC89937
PubMed Central ID: PMC89937
PubMed ID: 10817733
Date Deposited: 05 Dec 2012 16:39
Last Modified: 27 Sep 2022 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/16637

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