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Health-related quality of life, adiposity, and sedentary behavior in patients with early schizophrenia: Preliminary study

Strassnig, M and Brar, JS and Ganguli, R (2012) Health-related quality of life, adiposity, and sedentary behavior in patients with early schizophrenia: Preliminary study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 5. 389 - 394. ISSN 1178-7007

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Abstract

Objective: To examine adiposity and sedentary behavior in relation to health-related quality of life (QoL) in patients with early schizophrenia. Methods: A cross-sectional study was used to assess adiposity by dual-energy X-ray absorptiometry scans, habitual physical activity and idle sitting time by the Short Form International Physical Activity Questionnaire, and health-related QoL by the RAND Medical Outcomes Study SF-36. QoL scores were compared with age-adjusted Canadian normative population data. Results: There were 36 participants with early schizophrenia, average age 25.1 (±3.6). Twenty-nine (72.5%) were males. Mean illness duration was 30 (±18) months, and mean body mass index was 28.3 (±5). Females had higher body fat content than males (30.8±6.9 vs 24.7±10.6; t=-2.6, df=34; P=0.015). Total body fat (F=14; P=0.001), lean body mass (F=10.2; P=0.001), and sedentary behavior (F=5; P=0.013) significantly increased across body mass index categories. Total body fat was correlated with sedentary behavior (r=0.62; P=0.001), and total lean body mass was negatively correlated with sedentary behavior (r=0.39; P=0.03). Based on SF-36scores, participants had significantly lower physical functioning (P=0.0034), role physical (P=0.0003), general health (P,0.0001), vitality (P=0.03), and physical component scores (P=0.003) than Canadian population comparisons. Habitual sedentary behavior, more than activity or adiposity levels, was associated with health-related QoL in early schizophrenia. Conclusion: Health-related QoL is lower in early schizophrenia and is predominantly experienced in the physical domain. QoL in early schizophrenia relates to sedentary behavior more than to activity and adiposity levels. © 2012 Strassnig etal, publisher and licensee Dove Medical Press Ltd.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Strassnig, M
Brar, JSjsb11@pitt.eduJSB11
Ganguli, R
Date: 25 October 2012
Date Type: Publication
Journal or Publication Title: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume: 5
Page Range: 389 - 394
DOI or Unique Handle: 10.2147/dmso.s33619
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
ISSN: 1178-7007
Date Deposited: 03 Dec 2012 22:27
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/16702

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