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Intracameral dexamethasone reduces inflammation on the first postoperative day after cataract surgery in eyes with and without glaucoma

Chang, DTW and Herceg, MC and Bilonick, RA and Camejo, L and Schuman, JS and Noecker, RJ (2009) Intracameral dexamethasone reduces inflammation on the first postoperative day after cataract surgery in eyes with and without glaucoma. Clinical Ophthalmology, 3 (1). 345 - 355. ISSN 1177-5467

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Abstract

Purpose: To evaluate whether dexamethasone injected intracamerally at the conclusion of surgery can safely and effectively reduce postoperative inflammation and improve surgical outcomes in eyes with and without glaucoma. Methods: Retrospective chart review of 176 consecutive eyes from 146 patients receiving uncomplicated phacoemulsification (PE) (n = 118 total, 82 with glaucoma), glaucoma drainage device (GDD) (n = 35), combined PE/GDD (n = 11) and combined PE/endoscopic cyclophotocoagulation (n = 12). Ninety-one eyes from 76 patients were injected with 0.4 mg dexamethasone intracamerally at the conclusion of surgery. All eyes received standard postoperative prednisolone and ketorolac eyedrops. Outcomes were measured for four to eight weeks by subjective complaints, visual acuity (VA), slit-lamp biomicroscopy, intraocular pressure (IOP) and postoperative complications. Results: Dexamethasone significantly reduced the odds of having an increased anterior chamber (AC) cell score after PE (p = 0.0013). Mean AC cell score ± SD in nonglaucomatous eyes was 1.3 ± 0.8 in control and 0.8 ± 0.7 with dexamethasone; scores in glaucomatous eyes were 1.3 ± 0.7 in control and 0.9 ± 0.8 with dexamethasone. Treated nonglaucomatous eyes had significantly fewer subjective complaints after PE (22.2% vs 64.7% in control; p = 0.0083). Dexamethasone had no significant effects on VA, corneal changes, IOP one day and one month after surgery, or long-term complications. Conclusions: Intracameral dexamethasone given at the end of cataract surgery significantly reduces postoperative AC cells in eyes with and without glaucoma, and improves subjective reports of recovery in nonglaucomatous eyes. There were no statistically significant risks of IOP elevation or other complications in glaucomatous eyes. © 2009 Chang et al, publisher and licensee Dove Medical Press Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chang, DTW
Herceg, MC
Bilonick, RArab45@pitt.eduRAB45
Camejo, L
Schuman, JSjss28@pitt.eduJSS280000-0002-8885-3766
Noecker, RJ
Date: 1 January 2009
Date Type: Publication
Journal or Publication Title: Clinical Ophthalmology
Volume: 3
Number: 1
Page Range: 345 - 355
DOI or Unique Handle: 10.2147/opth.s5730
Schools and Programs: School of Medicine > Ophthalmology
Refereed: Yes
ISSN: 1177-5467
Date Deposited: 12 Dec 2012 21:12
Last Modified: 06 Jun 2020 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/16887

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