Gingo, MR and Balasubramani, GK and Kingsley, L and Rinaldo, CR and Alden, CB and Detels, R and Greenblatt, RM and Hessol, NA and Holman, S and Huang, L and Kleerup, EC and Phair, J and Sutton, SH and Seaberg, EC and Margolick, JB and Wisniewski, SR and Morris, A
(2013)
The Impact of HAART on the Respiratory Complications of HIV Infection: Longitudinal Trends in the MACS and WIHS Cohorts.
PLoS ONE, 8 (3).
Abstract
Objective: To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART). Design: Two large observational cohorts of HIV-infected and HIV-uninfected men (Multicenter AIDS Cohort Study [MACS]) and women (Women's Interagency HIV Study [WIHS]), followed since 1984 and 1994, respectively. Methods: Adjusted odds or hazards ratios for incident respiratory infections or non-infectious respiratory diagnoses, respectively, in HIV-infected compared to HIV-uninfected individuals in both the pre-HAART (MACS only) and HAART eras; and adjusted Cox proportional hazard ratios for mortality in HIV-infected persons with lung disease during the HAART era. Results: Compared to HIV-uninfected participants, HIV-infected individuals had more incident respiratory infections both pre-HAART (MACS, odds ratio [adjusted-OR], 2.4; 95% confidence interval [CI], 2.2-2.7; p<0.001) and after HAART availability (MACS, adjusted-OR, 1.5; 95%CI 1.3-1.7; p<0.001; WIHS adjusted-OR, 2.2; 95%CI 1.8-2.7; p<0.001). Chronic obstructive pulmonary disease was more common in MACS HIV-infected vs. HIV-uninfected participants pre-HAART (hazard ratio [adjusted-HR] 2.9; 95%CI, 1.02-8.4; p = 0.046). After HAART availability, non-infectious lung diseases were not significantly more common in HIV-infected participants in either MACS or WIHS participants. HIV-infected participants in the HAART era with respiratory infections had an increased risk of death compared to those without infections (MACS adjusted-HR, 1.5; 95%CI, 1.3-1.7; p<0.001; WIHS adjusted-HR, 1.9; 95%CI, 1.5-2.4; p<0.001). Conclusion: HIV infection remained a significant risk for infectious respiratory diseases after the introduction of HAART, and infectious respiratory diseases were associated with an increased risk of mortality. © 2013 Gingo et al.
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Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Gingo, MR | mrg35@pitt.edu | MRG35 | | Balasubramani, GK | BalaGK@edc.pitt.edu | BKG10 | 0000-0001-7221-1825 | Kingsley, L | kingsley@pitt.edu | KINGSLEY | | Rinaldo, CR | | | | Alden, CB | | | | Detels, R | | | | Greenblatt, RM | | | | Hessol, NA | | | | Holman, S | | | | Huang, L | | | | Kleerup, EC | | | | Phair, J | | | | Sutton, SH | | | | Seaberg, EC | | | | Margolick, JB | | | | Wisniewski, SR | STEVEWIS@pitt.edu | STEVEWIS | | Morris, A | | | |
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Date: |
12 March 2013 |
Date Type: |
Publication |
Journal or Publication Title: |
PLoS ONE |
Volume: |
8 |
Number: |
3 |
DOI or Unique Handle: |
10.1371/journal.pone.0058812 |
Schools and Programs: |
School of Public Health > Epidemiology School of Public Health > Infectious Diseases and Microbiology School of Medicine > Immunology School of Medicine > Medicine School of Medicine > Pathology |
Refereed: |
Yes |
Date Deposited: |
08 Apr 2013 17:14 |
Last Modified: |
18 May 2020 13:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/17877 |
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