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CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II SIGNALING AND IGFR SIGNALING ARE COUNTER-BALANCED TO REGULATE PROTEIN DEGRADATION IN C. ELEGANS MUSCLE

Feather, Caitlin (2014) CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II SIGNALING AND IGFR SIGNALING ARE COUNTER-BALANCED TO REGULATE PROTEIN DEGRADATION IN C. ELEGANS MUSCLE. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

The signal transduction network controlling protein degradation in the striated body-wall muscle of C. elegans has been shown to be composed of stimulatory signaling from the FGF receptor and inhibitory signaling from the IGF receptor engaged in cross talk at the level of the Raf-MEK-MAPK cascade. Calcium/calmodulin-dependent protein kinase II (CaMKII) is an additional, pro-degradation input into the network at the level of Raf. Splice forms of CaMKII may play a role in effective CaMKII signaling. The IGFR/FGFR/CaMKII network regulates protein degradation via autophagy. Degradation caused by increase of the pro-degradation signal from CaMKII can be suppressed by increase of opposing IGFR signaling, and degradation caused by decrease in the IGFR signal can be suppressed by decreased CaMKII signaling. This implies that regulation of protein degradation is based on integration of multiple signals by Raf and not on absolute amounts of individual signals.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Feather, Caitlinseefeather@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairGrabowski, Paula J.pag4@pitt.eduPAG4
Committee MemberKiselyov, Kirillkiselyov@pitt.eduKISELYOV
Committee MemberStonach, Bethstronach@pitt.eduSTRONACH
Committee MemberSilverman, Garygsilverman@upmc.edu
Committee MemberJacobson, Lewis Aljac@pitt.eduLJAC
Date: 28 January 2014
Date Type: Publication
Defense Date: 10 September 2013
Approval Date: 28 January 2014
Submission Date: 6 November 2013
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 147
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: signaling, C. elegans, FGFR, IGFR, calcium, Raf, Mek, MAPK, FEM-2, autophagy, muscle, protein, degradation, integrated, network, splice, CaMKII
Date Deposited: 28 Jan 2014 19:39
Last Modified: 15 Nov 2016 14:15
URI: http://d-scholarship.pitt.edu/id/eprint/20104

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  • CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II SIGNALING AND IGFR SIGNALING ARE COUNTER-BALANCED TO REGULATE PROTEIN DEGRADATION IN C. ELEGANS MUSCLE. (deposited 28 Jan 2014 19:39) [Currently Displayed]

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