Brody, Daniel M.
(2014)
Synthesis of Simplified Discodermolide Analogs.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Discodermolide was discovered in 1990 and with its discovery set off an expansive
medicinal chemistry program fueled by many groups’ research. It acts as a microtubule
stabilizer, which makes it a potential anti-cancer agent. The synthesis of simplified
discodermolide analogs is reported here. These analogs use simplified versions of the lactone
and carbamate fragments, which are then coupled via olefin metathesis. Hologram quantitative
structure-activity relationship (HQSAR) is also used to show that an olefin linker inserted by
olefin metathesis as viable simple alternatives to the complex middle portion usually found in the
parent molecule.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
27 January 2014 |
| Date Type: |
Publication |
| Defense Date: |
19 November 2013 |
| Approval Date: |
27 January 2014 |
| Submission Date: |
6 December 2013 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
170 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Discodermolide, Microtubules, Microtubule stabilizers |
| Date Deposited: |
27 Jan 2014 16:48 |
| Last Modified: |
15 Nov 2016 14:16 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/20243 |
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