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Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives

Manoach, DS and Demanuele, C and Wamsley, EJ and Vangel, M and Montrose, DM and Miewald, J and Kupfer, D and Buysse, D and Stickgold, R and Keshavan, MS (2014) Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives. Frontiers in Human Neuroscience, 8 (OCT).

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Abstract

Introduction: Chronic medicated patients with schizophrenia have marked reductions in sleep spindle activity and a correlated deficit in sleep-dependent memory consolidation. Using archival data, we investigated whether antipsychotic-naïve early course patients with schizophrenia and young non-psychotic first-degree relatives of patients with schizophrenia also show reduced sleep spindle activity and whether spindle activity correlates with cognitive function and symptoms.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Manoach, DS
Demanuele, C
Wamsley, EJ
Vangel, M
Montrose, DMDMM159@pitt.eduDMM159
Miewald, J
Kupfer, Ddjkupfer@pitt.eduDJKUPFER
Buysse, Dbuysse@pitt.eduBUYSSE
Stickgold, R
Keshavan, MSkeshavan@pitt.eduKESHAVAN
Date: 7 October 2014
Date Type: Publication
Journal or Publication Title: Frontiers in Human Neuroscience
Volume: 8
Number: OCT
DOI or Unique Handle: 10.3389/fnhum.2014.00762
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 22 May 2015 21:45
Last Modified: 03 Apr 2021 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/24737

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