Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form
D-Scholarship @ Pitt Banner and Links to Homepage

Intranasal dexmedetomidine as a sedative premedication for patients undergoing suspension laryngoscopy: A randomized double-blind study

Lu, C and Zhang, LM and Zhang, Y and Ying, Y and Li, L and Xu, L and Ruan, X (2016) Intranasal dexmedetomidine as a sedative premedication for patients undergoing suspension laryngoscopy: A randomized double-blind study. PLoS ONE, 11 (5).

[img]
Preview
 PDF
Published Version
Available under License : See the attached license file.
Download (358kB)
[img] Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)

Abstract

Background: Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable perioperative anxiolysis in children. We investigate intranasal dexmedetomidine as a sedative premedication for anesthesia recovery in an adult population. Methods: A prospective randomized controlled trial; 81 adult patients scheduled for elective suspension laryngoscopy received intranasal dexmedetomidine (1 μg·kg-1) or a placebo 45-60 min before anesthetic induction. Extubation time was used as the primary outcome measure. Secondary variables included the levels of sedation (Observer's Assessment of Alertness/Sedation scale, OAA/S) and anxiety (4-point anxiety score), anesthetic and analgesic requirements, hemodynamic fluctuations, and anesthesia recovery as well as side effects. Results: The levels of sedation and anxiety differed significantly between the two groups at anesthesia pre-induction (p < 0.001 and = 0.001, respectively). Repeated-measure general linear model determined no significant interaction effect between group and time on the targeted concentration of propofol (F = 1.635, p = 0.200), but a significant main effect of group existed (F = 6.880, p = 0.010). A moderate but significant decrease in the heart rate was recorded in the dexmedetomidine group at pre-induction. Episodes of tachycardia and hypertension after tracheal intubation and extubation were more frequent in the placebo group. Conclusions: Intranasal dexmedetomidine as a sedative premedication induced a favorable perioperative anxiolysis without prolongation in anesthesia recovery; the hemodynamic effect was modest. Trial Registration: ClinicalTrials.gov NCT 02108171.

Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lu, C
Zhang, LMliz19@pitt.eduLIZ190000-0003-3351-801X
Zhang, Y
Ying, Y
Li, L
Xu, L
Ruan, X
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorChopra, ArvindUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 May 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 11
Number: 5
DOI or Unique Handle: 10.1371/journal.pone.0154192
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Anesthesiology
Refereed: Yes
Date Deposited: 22 Dec 2016 16:02
Last Modified: 22 Jun 2021 11:55
URI: http://d-scholarship.pitt.edu/id/eprint/28231

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

Actions (login required)

View Item View Item