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Cell-type specific plasticity at intrapallidal synapses in a mouse model of Parkinson's Disease

Zitelli, Kevin (2016) Cell-type specific plasticity at intrapallidal synapses in a mouse model of Parkinson's Disease. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

The cell types that comprise neural networks are critical in determining their function.
Within the globus pallidus externa (GPe), a nucleus of the basal ganglia implicated in
Parkinsonism, several neuronal subpopulations have been described genetically and
anatomically, but functional and physiological studies have been limited. This study examines
the previously undescribed collateral connections between two key cell types in the GPe, defined
by the genetic expression of parvalbumin (PV) or LIM homeobox 6 (Lhx6). Further investigation
of this network in a mouse model of Parkinson’s Disease reveals a selective weakening of
synaptic input from PV to Lhx6 neurons following dopamine lesions. This study builds on recent
literature elucidating the roles of specific GPe cell types to basal ganglia function in health and
disease.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zitelli, Kevinkevin.zitelli@gmail.comKTZ30000-0002-2269-8775
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairGittis, Arynagittis@cmu.edu
Committee MemberTurner, Robertrturner+@pitt.edu
Committee MemberSusanne, Ahmariahmarise@upmc.edu
Date: 7 September 2016
Date Type: Publication
Defense Date: 11 August 2016
Approval Date: 7 September 2016
Submission Date: 12 August 2016
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 45
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Neurobiology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: globus pallidus externa, GPe, Parkinson's Disease, synaptic plasticity, slice electrophysiology, lateral inhibition
Date Deposited: 07 Sep 2016 15:02
Last Modified: 07 Sep 2017 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/29401

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