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Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population

Lee, CPL and Irwanto, A and Salim, A and Yuan, JM and Liu, J and Koh, WP and Hartman, M (2014) Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population. Breast Cancer Research, 16 (3). ISSN 1465-5411

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Abstract

Introduction: Genetic variants for breast cancer risk identified in genome-wide association studies (GWAS) in Western populations require further testing in Asian populations. A risk assessment model incorporating both validated genetic variants and established risk factors may improve its performance in risk prediction of Asian women.Methods: A nested case-control study of female breast cancer (411 cases and 1,212 controls) within the Singapore Chinese Health Study was conducted to investigate the effects of 51 genetic variants identified in previous GWAS on breast cancer risk. The independent effect of these genetic variants was assessed by creating a summed genetic risk score (GRS) after adjustment for body mass index and the Gail model risk factors for breast cancer.Results: The GRS was an independent predictor of breast cancer risk in Chinese women. The multivariate-adjusted odds ratios (95% confidence intervals) of breast cancer for the second, third, and fourth quartiles of the GRS were 1.26 (0.90 to 1.76), 1.47 (1.06 to 2.04) and 1.75 (1.27 to 2.41) respectively (P for trend <0.001). In addition to established risk factors, the GRS improved the classification of 6.2% of women for their absolute risk of breast cancer in the next five years.Conclusions: Genetic variants on top of conventional risk factors can improve the risk prediction of breast cancer in Chinese women. © 2014 Lee et al.; licensee BioMed Central Ltd.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lee, CPL
Irwanto, A
Salim, A
Yuan, JMyuanj@pitt.eduYUANJ
Liu, J
Koh, WP
Hartman, M
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 18 June 2014
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 16
Number: 3
DOI or Unique Handle: 10.1186/bcr3678
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1465-5411
Date Deposited: 19 Dec 2016 20:18
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/29543

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